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Product Name
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PAI1 antibody
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See all PAI1 / Serpine 1 antibodies (20)...
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Product type
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Primary antibodies
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Description
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Goat polyclonal to PAI1
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Immunogen
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Recombinant full length protein (Human).
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Reacts with
(species key)
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Hu
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Specificity
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There were no cross reactivities obtained with human tPA ; uPA; and PAI2
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Tested applications
(see key)
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ELISA, IHC-Fr, IHC-P, RIA
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent dilution.
IHC-P: 1/50. Perform pretreatment with 0.05% Pronase E (Sigma) for 20 minutes before commencing with IHC staining protocol.
IHC-Fr: 1/50 - 1/100.
RIA: Use at an assay dependent dilution.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted
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Research areas
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Cancer >> Tumor biomarkers >> Other
Cell Biology >> Proteolysis / Ubiquitin >> Protease inhibitors >> Serine protease inhibitors >> SERPINs
Cardiovascular >> Blood >> Fibrinolysis / Thrombolysis
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Relevance
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PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type palsminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Goat
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Whole antiserum
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this PAI1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to PAI1
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PAI1 antibody - more information
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Customer reviews (feedback) regarding PAI1 antibody |
Customer FAQs regarding PAI1 antibody |
Protocols for PAI1 antibody |
Price and availability of products related to PAI1 antibody |
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Contact Abcam with a Technical Enquiry about PAI1 antibody |
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