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Anti-PAI1 antibody (ab14197)

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Overview

Product name

Anti-PAI1 antibody
See all PAI1 products (19) ...

Description

Goat polyclonal to PAI1

Specificity

There were no cross reactivities obtained with human tPA ; uPA; and PAI2

Tested applications

ELISA, RIA, IHC-P, IHC-Frmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant full length protein (Human).

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Tumor biomarkers >> Other
Cell Biology >> Proteolysis / Ubiquitin >> Protease inhibitors >> Serine protease inhibitors >> SERPINs
Cardiovascular >> Blood >> Fibrinolysis / Thrombolysis

Applications

Show applications key

Our Abpromise guarantee covers the use of ab14197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    ELISA

     ELISA: Use at an assay d...Read more →

    ELISA: Use at an assay dependent dilution.

  • ShowHide

    RIA

     RIA: Use at an assay dep...Read more →

    RIA: Use at an assay dependent dilution.

  • ShowHide

    IHC-P

     IHC-P: 1/50(Pretreat wit...Read more →

    IHC-P: 1/50(Pretreat with 0.05% Pronase for 20 minutes before commencing with IHC staining protocol.)

  • IHC-Fr

     IHC-Fr: 1/50 - 1/100.

    IHC-Fr: 1/50 - 1/100.

Target

Function

This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.

Tissue specificity

Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.

Involvement in disease

Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.
Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions.

Sequence similarities

Belongs to the serpin family.

Post-translational
modifications

Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-
-Met-370 bond.

Cellular localization

Secreted.

Target information above from: UniProt accessionP05121 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Clade E antibody
  • Endothelial plasminogen activator inhibitor antibody
  • Nexin antibody
  • PAI 1 antibody
  • PAI antibody
  • PAI-1 antibody
  • PAI1_HUMAN antibody
  • PLANH1 antibody
  • Plasminogen activator inhibitor 1 antibody
  • Plasminogen activator inhibitor type 1 antibody
  • Serine (or cysteine) proteinase inhibitor antibody
  • Serpin E1 antibody
  • Serpin peptidase inhibitor clade E antibody
  • Serpine 1 antibody
  • Serpine1 antibody
see all

Database links

References for Anti-PAI1 antibody (ab14197)

ab14197 has not yet been referenced specifically in any publications.

Publishing research using ab14197? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"