Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionActivates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2.
Tissue specificityHighest expression in prostate, testis and colon.
Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 CRIB domain. Contains 1 protein kinase domain.
Post-translational modificationsAutophosphorylated on serine residues when activated by CDC42/p21. Phosphorylated on tyrosine residues upon stimulation of FGFR2.
P21 protein (Cdc42/Rac) activated kinase 4 antibody
p21(CDKN1A) activated kinase 4 antibody
p21-activated kinase 4 antibody
PAK 4 antibody
Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs antibody
Serine threonine kinase PAK 4 antibody
Serine/threonine protein kinase PAK 4 antibody
Serine/threonine protein kinase PAK4 antibody
Serine/threonine-protein kinase PAK 4 antibody
Anti-PAK4 antibody images
Western blot - Anti-PAK4 antibody (ab17974)
Predicted band size : 64 kDa
Detection of Human PAK4 by Western Blot following Immunoprecipitation. Samples: Whole cell lysate from HeLa (5 x 106) or Jurkat (25 x 106) cells. Antibody: Affinity purified rabbit anti-PAK4 (ab17974) used at 4 mcg for IP and at 1 mcg/ml for Western Blot. Detection: Chemiluminescence.
References for Anti-PAK4 antibody (ab17974)
has not yet been referenced specifically in any publications.
Publishing research using ab17974? Please let us know so that we can cite the reference in this datasheet.
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