Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Immunology >> Immunoglobulins >> Receptors
Overview
Product name
Anti-pan CEACAM antibody [TET2]
See all pan CEACAM products (2) ...
Description
Mouse monoclonal [TET2] to pan CEACAM
Specificity
ab26283 is a broadly reactive antibody which reacts with most of the CEACAM molecules characterized to date (except CEACAM3, CEACAM4 and CEACAM7)4. It can be used to detect CEACAM1 (BGP/CD66a), CEACAM5 (CEA/CD66e), CEACAM6 (NCA/CD66c) and CEACAM8 (CGM6/CD66b) on transiently transfected BOSC23 cells by flow cytometry.
Tested applications
Flow Cyt, ELISA, WB, IHC-Fr, IPmore details
Cross reactivity
Reacts with
Human
Immunogen
ab26283 was generated by immunisation of BALB/c mice with CEA partially purified from a perchloric acid extract from liver metastases of colonic tumors.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.01% Sodium Azide
Constituents: PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
TET2
Isotype
IgG2b
Research areas
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
Immunology >> Immunoglobulins >> Receptors
Applications
Show applications key
Our Abpromise guarantee covers the use of ab26283 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt: Use at an assay dependent dilution.
ELISA: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution.
IHC-Fr: Use at an assay dependent dilution.
IP: Use at an assay dependent concentration. (PubMed: 21645414NK cells were isolated from whole PBMC by negative magnetic bead fractionation.)
Target
Relevance
CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
Cellular localization
Cell Membrane
Alternative names
- Antigen CD66 antibody
- BGP 1 antibody
- BGP antibody
see all
Database links
- Entrez Gene: 1048 Human
- Entrez Gene: 1084 Human
- Entrez Gene: 1089 Human
- Entrez Gene: 4680 Human
- Entrez Gene: 634 Human
- SwissProt: O75871 Human
- SwissProt: P06731 Human
- SwissProt: P40198 Human
see all
References for Anti-pan CEACAM antibody [TET2] (ab26283)
This product has been referenced in:
- Moreland AJet al. Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques. BMC Genomics 12:295 (2011). IP; Rhesus monkey.Read more (PubMed: 21645414) »
- Graham SAet al. Identification of Neutrophil Granule Glycoproteins as Lewisx-containing Ligands Cleared by the Scavenger Receptor C-type Lectin. J Biol Chem 286:24336-49 (2011). WB.Read more (PubMed: 21561871) »
See all 2 publications for this product
Publishing research using ab26283? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"