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Product Name
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pan CEACAM antibody [TET2]
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See all pan CEACAM antibodies (2)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [TET2] to pan CEACAM
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Immunogen
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ab26283 was generated by immunisation of BALB/c mice with CEA partially purified from a perchloric acid extract from liver metastases of colonic tumors.
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Reacts with
(species key)
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Hu
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Specificity
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ab26283 is a broadly reactive antibody which reacts with most of the CEACAM molecules characterized to date (except CEACAM3, CEACAM4 and CEACAM7)4. It can be used to detect CEACAM1 (BGP/CD66a), CEACAM5 (CEA/CD66e), CEACAM6 (NCA/CD66c) and CEACAM8 (CGM6/CD66b) on transiently transfected BOSC23 cells by flow cytometry.
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Tested applications
(see key)
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ELISA, Flow Cyt, IHC-Fr, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA and cell-ELISA: Use at an assay dependent dilution.
Flow Cyt: Use at an assay dependent dilution.
IHC-Fr: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell Membrane
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Research areas
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Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
Immunology >> Immunoglobulins >> Receptors
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Relevance
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CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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TET2
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Isotype
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IgG2b
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Purity
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Protein G purified
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Storage buffer
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Preservative: 0.01% Sodium Azide
Constituents: PBS, pH 7.2 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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2.000 mg/ml
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Storage instructions
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Store at +4°C.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this pan CEACAM antibody [TET2] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to pan CEACAM
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pan CEACAM antibody [TET2] - more information
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Customer reviews (feedback) regarding pan CEACAM antibody [TET2] |
Customer FAQs regarding pan CEACAM antibody [TET2] |
Protocols for pan CEACAM antibody [TET2] |
Price and availability of products related to pan CEACAM antibody [TET2] |
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pan CEACAM antibody [TET2] - related products:
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pan CEACAM antibody [TET2] - other tools:
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Contact Abcam with a Technical Enquiry about pan CEACAM antibody [TET2] |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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