Anti-pan-AKT (phospho T308) antibody (ab38449)

ab38449 has been referenced in 42 publications.

• Abou-Antoun TJ  et al. Molecular and functional analysis of anchorage independent, treatment-evasive neuroblastoma tumorspheres with enhanced malignant properties: A possible explanation for radio-therapy resistance. PLoS One 13:e0189711 (2018). PubMed: 29298329
• Jiang MP  et al. ß-arrestin 2 attenuates lipopolysaccharide-induced liver injuryviainhibition of TLR4/NF-?B signaling pathway-mediated inflammation in mice. World J Gastroenterol 24:216-225 (2018). PubMed: 29375207
• Lu H  et al. Decreased phosphorylation of PDGFR-ß impairs the angiogenic potential of expanded endothelial progenitor cells via the inhibition of PI3K/Akt signaling. Int J Mol Med 39:1492-1504 (2017). WB ; Human . PubMed: 28487975
• Zhang D  et al. Fibulin-4 promotes osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition via the PI3K/Akt/mTOR pathway. Int J Oncol 50:1513-1530 (2017). WB ; Human . PubMed: 28339091
• Chen S  et al. Long non-coding RNA PTENP1 inhibits proliferation and migration of breast cancer cells via AKT and MAPK signaling pathways. Oncol Lett 14:4659-4662 (2017). WB ; Human . PubMed: 29085464
• Huang XY  et al. Missing-in-metastasis B (MIM-B) combined with caveolin-1 promotes metastasis of hepatocellular carcinoma. Oncotarget 8:95450-95465 (2017). PubMed: 29221140
• Li L  et al. Expression of the ß3 subunit of Na+/K+-ATPase is increased in gastric cancer and regulates gastric cancer cell progression and prognosis via the PI3/AKT pathway. Oncotarget 8:84285-84299 (2017). PubMed: 29137423
• Ross JL  et al. 5-Aminolevulinic Acid Guided Sampling of Glioblastoma Microenvironments Identifies Pro-Survival Signaling at Infiltrative Margins. Sci Rep 7:15593 (2017). PubMed: 29142297
• Zheng Y  et al. The extracellular vesicles secreted by lung cancer cells in radiation therapy promote endothelial cell angiogenesis by transferring miR-23a. PeerJ 5:e3627 (2017). WB ; Human . PubMed: 28852584
• Luo J  et al. Ursolic acid inhibits breast cancer growth by inhibiting proliferation, inducing autophagy and apoptosis, and suppressing inflammatory responses via the PI3K/AKT and NF-?B signaling pathwaysin vitro. Exp Ther Med 14:3623-3631 (2017). PubMed: 29042957
• Liu Y  et al. The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway. Oncol Lett 13:4685-4690 (2017). PubMed: 28599470
• Shi Y  et al. SNP rs3202538 in 3'UTR region of ErbB3 regulated by miR-204 and miR-211 promote gastric cancer development in Chinese population. Cancer Cell Int 17:81 (2017). PubMed: 28924391
• Wang P  et al. Long Noncoding RNA H19 Inhibits Cell Viability, Migration, and Invasion Via Downregulation of IRS-1 in Thyroid Cancer Cells. Technol Cancer Res Treat 16:1102-1112 (2017). PubMed: 29332545
• Zhang W  et al. LKB1 loss cooperating with BRAF V600E promotes melanoma cell invasion and migration by up-regulation MMP-2 via PI3K/Akt/mTOR pathway. Oncotarget 8:113847-113857 (2017). PubMed: 29371951
• Li R  et al. Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells. Oncotarget 8:19354-19364 (2017). WB ; Human . PubMed: 28423613
• Li Y  et al. MicroRNA-210 induces endothelial cell apoptosis by directly targeting PDK1 in the setting of atherosclerosis. Cell Mol Biol Lett 22:3 (2017). WB . PubMed: 28536634
• Wang C  et al. Neuroprotective mechanisms of miR-124 activating PI3K/Akt signaling pathway in ischemic stroke. Exp Ther Med 13:3315-3318 (2017). WB . PubMed: 28587406
• Deng YP  et al. Human bocavirus induces apoptosis and autophagy in human bronchial epithelial cells. Exp Ther Med 14:753-758 (2017). PubMed: 28672995
• Yu J  et al. miR-340 Inhibits Proliferation and Induces Apoptosis in Gastric Cancer Cell Line SGC-7901, Possibly via the AKT Pathway. Med Sci Monit 23:71-77 (2017). PubMed: 28057912
• Lv B  et al. Activated Microglia Induce Bone Marrow Mesenchymal Stem Cells to Produce Glial Cell-Derived Neurotrophic Factor and Protect Neurons Against Oxygen-Glucose Deprivation Injury. Front Cell Neurosci 10:283 (2016). PubMed: 28018176
• Pang X  et al. Role of miR-145 in chronic constriction injury in rats. Exp Ther Med 12:4121-4127 (2016). PubMed: 28105140
• Juvekar A  et al. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proc Natl Acad Sci U S A 113:E4338-47 (2016). WB, ICC/IF ; Mouse . PubMed: 27402769
• Tu M  et al. MicroRNA-127-5p regulates osteopontin expression and osteopontin-mediated proliferation of human chondrocytes. Sci Rep 6:25032 (2016). WB ; Human . PubMed: 27126955
• Lu H  et al. Transient hypoxia reprograms differentiating adipocytes for enhanced insulin sensitivity and triglyceride accumulation. Int J Obes (Lond) 40:121-8 (2016). Mouse . PubMed: 26219415
• Qin G  et al. Melittin inhibits tumor angiogenesis modulated by endothelial progenitor cells associated with the SDF-1a/CXCR4 signaling pathway in a UMR-106 osteosarcoma xenograft mouse model. Mol Med Rep 14:57-68 (2016). WB . PubMed: 27177128
• Yang R  et al. Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling. Mol Med Rep 13:4175-82 (2016). WB ; Human . PubMed: 27035679
• Li T  et al. Wen-Xin Decoction ameliorates vascular endothelium dysfunction via the PI3K/AKT/eNOS pathway in experimental atherosclerosis in rats. BMC Complement Altern Med 16:27 (2016). Rat . PubMed: 26803585
• Li XJ  et al. Bergapten exerts inhibitory effects on diabetes-related osteoporosis via the regulation of the PI3K/AKT, JNK/MAPK and NF-?B signaling pathways in osteoprotegerin knockout mice. Int J Mol Med N/A:N/A (2016). WB ; Mouse . PubMed: 27840967
• Yang Z  et al. Phosphorylation and inactivation of PTEN at residues Ser380/Thr382/383 induced by Helicobacter pylori promotes gastric epithelial cell survival through PI3K/Akt pathway. Oncotarget 6:31916-26 (2015). IHC-P ; Human . PubMed: 26376616
• Gu YJ  et al. GRP78 confers the resistance to 5-FU by activating the c-Src/LSF/TS axis in hepatocellular carcinoma. Oncotarget 6:33658-74 (2015). WB . PubMed: 26378040
• Kaczmarek MZ  et al. Mechanism of action for the cytotoxic effects of the nitric oxide prodrug JS-K in murine erythroleukemia cells. Leuk Res 38:377-82 (2014). PubMed: 24461365
• Nteeba J  et al. Impact of obesity on ovotoxicity induced by 7,12-dimethylbenz[a]anthracene in mice. Biol Reprod 90:68 (2014). WB ; Mouse . PubMed: 24501177
• Agbemenyah HY  et al. Insulin growth factor binding protein 7 is a novel target to treat dementia. Neurobiol Dis N/A:N/A (2013). WB ; Mouse, Human . PubMed: 24075854
• Choudhary S  et al. Macrophage migratory inhibitory factor promotes bladder cancer progression via increasing proliferation and angiogenesis. Carcinogenesis 34:2891-9 (2013). WB ; Mouse . PubMed: 23825153
• Fleming GF  et al. Phase II trial of temsirolimus in patients with metastatic breast cancer. Breast Cancer Res Treat 136:355-63 (2012). PubMed: 22245973
• Hafner C  et al. Activation of the PI3K/AKT pathway in Merkel cell carcinoma. PLoS One 7:e31255 (2012). IHC-P ; Human . PubMed: 22363598
• Nickkho-Amiry M  et al. Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma. Mol Cancer Res 10:441-53 (2012). WB ; Human . PubMed: 22205725
• He Q  et al. Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia. Am J Physiol Endocrinol Metab 300:E877-85 (2011). PubMed: 21343542
• Manetti M  et al. Overexpression of VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, leads to insufficient angiogenesis in patients with systemic sclerosis. Circ Res 109:e14-26 (2011). Human . PubMed: 21636803
• Liang R  et al. Post-transcriptional regulation of IGF1R by key microRNAs in long-lived mutant mice. Aging Cell 10:1080-8 (2011). PubMed: 21967153
• Hartz AM  et al. Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein. J Pharmacol Exp Ther 334:467-76 (2010). WB ; Rat . PubMed: 20460386
• Wagner M  et al. Selective expansion of the {beta}-cell compartment in the pancreas of keratinocyte growth factor transgenic mice. Am J Physiol Gastrointest Liver Physiol : (2008). PubMed: 18372394