Anti-pan Sodium Channel antibody (ab53724)
Key features and details
- Rabbit polyclonal to pan Sodium Channel
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-pan Sodium Channel antibody -
Description
Rabbit polyclonal to pan Sodium Channel -
Host species
Rabbit -
Specificity
Detects endogenous levels of total sodium channel protein. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide corresponding to Human pan Sodium Channel.
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Positive control
- Extracts from HuvEc cells.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS
Without Mg+2 and Ca+2 -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab53724 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Detects a band of approximately 227 kDa (predicted molecular weight: 227 kDa).
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Notes |
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WB
1/500 - 1/1000. Detects a band of approximately 227 kDa (predicted molecular weight: 227 kDa). |
Target
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Relevance
The pan sodium ion channel, SCN5A, is a cardiac sodium channel distinct from those in nerve and muscle. It is a tetrodotoxin-resistant Na(+) channel isoform. SCN5A mediates the voltage-dependent sodium ion permeability of excitable membranes by opening or closing in response to the voltage difference across the membrane. Na(+) ions pass in accordance with their electrochemical gradient. This channel is responsible for the initial upstroke of the action potential in the electrocardiogram. Defects in SCN5A are involved in many diseases including: progressive familial heart block type I (PFHBI), also known as Lenegre-Lev disease or progressive cardiac conduction defect (PCCD); long QT syndrome type 3 (LQT3); Brugada syndrome; sick sinus syndrome 1 (SSS1); idiopathic ventricular fibrillation (IVF), also called paroxysmal familial ventricular fibrillation; sudden infant death syndrome (SIDS); familial atrial standstill and dilated cardiomyopathy 1E (CMD1E). -
Cellular localization
Cell Membrane; Multi-pass membrane protein. -
Database links
- Entrez Gene: 6331 Human
- Entrez Gene: 20271 Mouse
- Entrez Gene: 25665 Rat
- Omim: 600163 Human
- SwissProt: P35498 Human
- SwissProt: P35499 Human
- SwissProt: Q14524 Human
- SwissProt: Q15858 Human
see all -
Alternative names
- HBSC II antibody
- HH1 antibody
- hNaN antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab53724 has been referenced in 1 publication.
- Demers J et al. Atrial Electrical Remodeling in Mice With Cardiac-Specific Overexpression of Angiotensin II Type 1 Receptor. J Am Heart Assoc 11:e023974 (2022). PubMed: 35435021