• Product nameAnti-PANK2 antibody
    See all PANK2 primary antibodies
  • Description
    Rabbit polyclonal to PANK2
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide from the central region of human PANK2 conjugated to KLH.

  • Positive control
    • Mouse liver tissue lysate.



Our Abpromise guarantee covers the use of ab71381 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesELISA: 1/1000.
    WB: 1/100 - 1/500. Detects bands of approximately 30 and 63 kDa (predicted molecular weight: 63 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay be the master regulator of the CoA biosynthesis.
    • Tissue specificityUbiquitous.
    • PathwayCofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
    • Involvement in diseaseDefects in PANK2 are the cause of neurodegeneration with brain iron accumulation type 1 (NBIA1) [MIM:234200]; also known as pantothenate kinase-associated neurodegeneration (PKAN) or Hallervorden-Spatz syndrome (HSS). It is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. Clinical manifestations include progressive muscle spasticity, hyperreflexia, muscle rigidity, dystonia, dysarthria, and intellectual deterioration which progresses to severe dementia over several years. It is clinically classified into classic, atypical, and intermediate phenotypes. Classic forms present with onset in the first decade, rapid progression, loss of independent ambulation within 15 years. Atypical forms have onset in the second decade, slow progression, maintenance of independent ambulation up to 40 years later. Intermediate forms manifest onset in the first decade with slow progression or onset in the second decade with rapid progression. Patients with early onset tend to also develop pigmentary retinopathy, whereas those with later onset tend to also have speech disorders and psychiatric features. All patients have the 'eye of the tiger' sign on brain MRI.
      Defects in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP) [MIM:607236]. HARP is a rare syndrome with many clinical similarities to NBIA1.
    • Sequence similaritiesBelongs to the type II pantothenate kinase family.
    • Cellular localizationCytoplasm and Mitochondrion.
    • Information by UniProt
    • Database links
    • Alternative names
      • 4933409I19Rik antibody
      • AI642621 antibody
      • C20orf48 antibody
      • Hallervorden Spatz syndrome antibody
      • HARP antibody
      • hPANK2 antibody
      • HSS antibody
      • MGC118448 antibody
      • MGC15053 antibody
      • mitochondrial antibody
      • NBIA1 antibody
      • PANK2 antibody
      • PANK2_HUMAN antibody
      • Pantothenate kinase 2 (Hallervorden Spatz syndrome) antibody
      • Pantothenate kinase 2 antibody
      • Pantothenate kinase 2 mitochondrial antibody
      • Pantothenic acid kinase 2 antibody
      • PKAN antibody
      • RP23 387C21.4 antibody
      see all

    Anti-PANK2 antibody images

    • Anti-PANK2 antibody (ab71381) at 1/40 dilution + mouse liver tissue lysate at 35 µg

      Predicted band size : 63 kDa
      Observed band size : 63 kDa
      Additional bands at : 30 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-PANK2 antibody (ab71381)

    ab71381 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab71381.
    Please use the links above to contact us or submit feedback about this product.