Overview

  • Product name
  • Description
    Rabbit polyclonal to PAPP A2
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region from the N-terminus of Human PAPP A2.

  • Positive control
    • Human Heart and Placenta tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab117743 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 199 kDa.Can be blocked with PAPP A2 peptide (ab215817).
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function
    Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.
  • Tissue specificity
    Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.
  • Sequence similarities
    Belongs to the peptidase M43B family.
    Contains 5 Sushi (CCP/SCR) domains.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • PAPPA 2 antibody
    • PAPP E antibody
    • PAPP-A2 antibody
    • PAPP-E antibody
    • PAPP2_HUMAN antibody
    • PAPPA2 antibody
    • Pappalysin 2 antibody
    • Pappalysin-2 antibody
    • PLAC3 antibody
    • Pregnancy associated plasma protein A2 antibody
    • Pregnancy associated plasma protein E1 antibody
    • Pregnancy-associated plasma protein A2 antibody
    • Pregnancy-associated plasma protein E1 antibody
    see all

Images

  • ab117743, at 5 µg/ml, staining PAPP A2 in Formalin-fixed, Paraffin-embedded Human heart tissue by Immunohistochemistry.
  • ab117743, at 5 µg/ml, staining PAPP A2 in Formalin-fixed, Paraffin-embedded Human Placenta tissue by Immunohistochemistry.

References

ab117743 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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