The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/250. Detects a band of approximately 49-52 kDa (predicted molecular weight: 44 kDa).
FunctionReceptor for trypsin and trypsin-like enzymes coupled to G proteins that stimulate phosphoinositide hydrolysis. May have a role in the regulation of vascular tone.
Tissue specificityWidely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Post-translational modificationsA proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.