Anti-PAR4 antibody - C-terminal, prediluted (ab15511)

Overview

  • Product name
    Anti-PAR4 antibody - C-terminal, prediluted
    See all PAR4 primary antibodies
  • Description
    Rabbit polyclonal to PAR4 - C-terminal, prediluted
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human PAR4 (C terminal).
    Database link: Q96IZ0

  • Positive control
    • IHC-P: Human heart tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab15511 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Primary antibody incubation for 10 minutes at room temperature.

Target

  • Function
    Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
  • Tissue specificity
    Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers.
  • Domain
    The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners.
    The SAC domain is a death-inducing domain selective for apoptosis induction in cancer cells. This domain is essential for nuclear entry, Fas activation, inhibition of NF-kappa-B activity and induction of apoptosis in cancer cells.
  • Post-translational
    modifications
    Preferentially phosphorylated at the Thr-163 by PKC in cancer cells.
  • Cellular localization
    Cytoplasm. Nucleus. Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2310001G03Rik antibody
    • PAR 4 antibody
    • PAR-4 antibody
    • Pawr antibody
    • PAWR_HUMAN antibody
    • PRKC Apoptosis WT1 Regulator antibody
    • PRKC apoptosis WT1 regulator protein antibody
    • Prostate apoptosis response 4 protein antibody
    • Prostate apoptosis response protein 4 antibody
    • prostate apoptosis response protein PAR-4 antibody
    • Transcriptional repressor Par-4-like protein PAWR antibody
    • Transcriptional repressor PAR4 antibody
    • WT1 Interacting Protein antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human heart tissue stained for PAR4 using ab15511 in immunohistochemical analysis.

References

ab15511 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab15511.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up