- Datasheet
- Specific References
- Protocols
Overview
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Product nameAnti-Parathyroid Hormone antibody [D1.5]
See all Parathyroid Hormone primary antibodies -
DescriptionMouse monoclonal [D1.5] to Parathyroid Hormone
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Host speciesMouse
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SpecificityAb14501 reacts with parathyroid hormone peptides (aa 53-68; 53-84; 7-84; 1-84); affinity: > 2 x 1010 l/mol. There are no cross reactivities with synthetic parathyroid hormone peptides (aa 1-10; 1-34; 1-38).
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Tested applicationsSuitable for: ELISA, IHC-P, IHC-Frmore details
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Species reactivityReacts with: Human
Predicted to work with: Cow, Dog, Cynomolgus monkey
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Immunogen
bTG conjugated synthetic peptide:
KKEDNVLVESHEKSLGEADKADVNVLTKAKSQ
, corresponding to amino acids 53-84 of Human Parathyroid Hormone.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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Storage bufferPreservative: None
Constituents: 0.1M PBS, pH 7.4 -
Concentration information loading... -
PurityProtein G purified
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ClonalityMonoclonal
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Clone numberD1.5
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IsotypeIgG1
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Research areas
Associated products
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Compatible Secondaries
Applications
Our Abpromise guarantee covers the use of ab14501 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA | Use at an assay dependent concentration. Use at a concentration of 500 ng/ml. ILMA: Use at a concentration of 500 ng/ml. |
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| IHC-P | Use a concentration of 2 µg/ml. | |
| IHC-Fr | Use a concentration of 2 µg/ml. |
Target
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FunctionPTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
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Involvement in diseaseDefects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
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Sequence similaritiesBelongs to the parathyroid hormone family.
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Cellular localizationSecreted.
- Information by UniProt
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Database links
- Entrez Gene: 280903 Cow
- Entrez Gene: 403986 Dog
- Entrez Gene: 5741 Human
- Omim: 168450 Human
- SwissProt: P01268 Cow
- SwissProt: P52212 Dog
- SwissProt: P01270 Human
- Unigene: 37045 Human
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Alternative names
- hPTH antibody
- Parathormone antibody
- Parathyrin antibody
see all
Protocols
References
ab14501 has not yet been referenced specifically in any publications.
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"