Anti-Parathyroid Hormone antibody [D1.5] (ab14501)

Overview

  • Product nameAnti-Parathyroid Hormone antibody [D1.5]
    See all Parathyroid Hormone primary antibodies
  • Description
    Mouse monoclonal [D1.5] to Parathyroid Hormone
  • SpecificityAb14501 reacts with parathyroid hormone peptides (aa 53-68; 53-84; 7-84; 1-84); affinity: > 2 x 1010 l/mol. There are no cross reactivities with synthetic parathyroid hormone peptides (aa 1-10; 1-34; 1-38).
  • Tested applicationsSuitable for: ELISA, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow, Dog, Cynomolgus Monkey
  • Immunogen

    bTG conjugated synthetic peptide:

    KKEDNVLVESHEKSLGEADKADVNVLTKAKSQ

    , corresponding to amino acids 53-84 of Human Parathyroid Hormone.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: None
    Constituents: 0.1M PBS, pH 7.4
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • Clone numberD1.5
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab14501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration. Use at a concentration of 500 ng/ml.
ILMA: Use at a concentration of 500 ng/ml.
IHC-P Use a concentration of 2 µg/ml.
IHC-Fr Use a concentration of 2 µg/ml.

Target

  • FunctionPTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
  • Involvement in diseaseDefects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
  • Sequence similaritiesBelongs to the parathyroid hormone family.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • hPTH antibody
    • Parathormone antibody
    • Parathyrin antibody
    • Parathyroid hormone 1 antibody
    • Parathyroid hormone antibody
    • PTH antibody
    • PTH1 antibody
    • PTH1 receptor antibody
    • PTH1R antibody
    • PTHR antibody
    • PTHR1 antibody
    • PTHY_HUMAN antibody
    see all

References for Anti-Parathyroid Hormone antibody [D1.5] (ab14501)

ab14501 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"