Anti-Parathyroid Hormone antibody [D1.5] (ab14501)

Overview

• Product nameAnti-Parathyroid Hormone antibody [D1.5]
  See all Parathyroid Hormone primary antibodies
• Description
  Mouse monoclonal [D1.5] to Parathyroid Hormone
• SpecificityAb14501 reacts with parathyroid hormone peptides (aa 53-68; 53-84; 7-84; 1-84); affinity: > 2 x 10¹⁰ l/mol. There are no cross reactivities with synthetic parathyroid hormone peptides (aa 1-10; 1-34; 1-38).
• Tested applicationsSuitable for: ELISA, IHC-P, IHC-Frmore details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Cow, Dog, Cynomolgus monkey
• Immunogen

  bTG conjugated synthetic peptide:

  KKEDNVLVESHEKSLGEADKADVNVLTKAKSQ

  , corresponding to amino acids 53-84 of Human Parathyroid Hormone.
  Run BLAST with Run BLAST with

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• Storage bufferPreservative: None
  Constituents: 0.1M PBS, pH 7.4
• Concentration information loading...
• PurityProtein G purified
• ClonalityMonoclonal
• Clone numberD1.5
• IsotypeIgG1
• Research areas
  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

Associated products

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

Applications

Target

• FunctionPTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
• Involvement in diseaseDefects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
• Sequence similaritiesBelongs to the parathyroid hormone family.
• Cellular localizationSecreted.

• Target information above from: UniProt accession P01270 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 280903 Cow
  • Entrez Gene: 403986 Dog
  • Entrez Gene: 5741 Human
  • Omim: 168450 Human
  • SwissProt: P01268 Cow
  • SwissProt: P52212 Dog
  • SwissProt: P01270 Human
  • Unigene: 37045 Human
• Alternative names
  • hPTH antibody
  • Parathormone antibody
  • Parathyrin antibody

  • Parathyroid hormone 1 antibody
  • Parathyroid hormone antibody
  • Prepro PTH antibody
  • Preproparathyroid hormone antibody
  • PTH antibody
  • PTH1 antibody
  • PTH1 receptor antibody
  • PTH1R antibody
  • PTHR antibody
  • PTHR1 antibody
  • PTHY_HUMAN antibody

  see all