The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
FunctionReceptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
Tissue specificityExpressed in most tissues. Most abundant in kidney, bone and liver.
Involvement in diseaseJansen metaphyseal chondrodysplasia Chondrodysplasia Blomstrand type Enchondromatosis multiple Eiken skeletal dysplasia Primary failure of tooth eruption
Sequence similaritiesBelongs to the G-protein coupled receptor 2 family.