Overview

  • Product nameAnti-PARC antibody
    See all PARC primary antibodies
  • Description
    Rabbit polyclonal to PARC
  • Tested applicationsSuitable for: ICC, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    17 amino acid synthetic peptide, conjugated to KLH, from the C terminal region of Human PARC

  • Positive control
    • Human testis tissue

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab115631 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC Use at an assay dependent concentration.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 281 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionCytoplasmic anchor protein in p53-associated protein complex. Regulates the subcellular localization of p53 and subsequent function. Seems to be part of an atypical cullin-RING-based E3 ubiquitin-protein ligase complex. In vitro, complexes of CUL9/PARC with either CUL7 or TP53 contain E3 ubiquitin-protein ligase activity.
  • Tissue specificityUbiquitously expressed in all tissues with highest expression in testis brain and kidney.
  • Sequence similaritiesBelongs to the cullin family.
    Contains 1 DOC domain.
    Contains 1 IBR-type zinc finger.
    Contains 2 RING-type zinc fingers.
  • DomainThe IBR domain is required for interaction with UBCH7 and UBCH8.
  • Post-translational
    modifications
    In vitro, self-ubiquitination in the presence of E1, E2 and ubiquitin.
    Neddylated.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • CUL-9 antibody
    • Cul9 antibody
    • CUL9_HUMAN antibody
    • Cullin-9 antibody
    • DKFZp686G1042 antibody
    • DKFZp686P2024 antibody
    • H7AP1 antibody
    • KIAA0708 antibody
    • OTTHUMP00000039816 antibody
    • p53 associated parkin like cytoplasmic protein antibody
    • p53-associated parkin-like cytoplasmic protein antibody
    • PARC antibody
    • parkin-like cytoplasmic p53 binding protein antibody
    • RP3 330M21.2 antibody
    • UbcH 7 associated protein 1 antibody
    • UbcH7 associated protein 1 antibody
    • UbcH7-associated protein 1 antibody
    see all

Anti-PARC antibody images

  • ab115631 at 5ug/ml staining PARC in Human testis tissue by immunohistochemistry (FFPE). Following primary incubation slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-PARC antibody (ab115631)

ab115631 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab115631.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"