Anti-PARL antibody (ab118554)
Key features and details
- Rabbit polyclonal to PARL
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-PARL antibody -
Description
Rabbit polyclonal to PARL -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Rat -
Immunogen
Synthetic peptide containing 15 amino acids from the N-terminal region of Human PARL (NP_061092.3).
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Positive control
- Human pancreas tissue; 3T3 cell lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab118554 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 42 kDa.
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IHC-P |
Use a concentration of 5 µg/ml.
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Notes |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 42 kDa. |
IHC-P
Use a concentration of 5 µg/ml. |
Target
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Function
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. -
Sequence similarities
Belongs to the peptidase S54 family. -
Post-translational
modificationsP-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated. -
Cellular localization
Mitochondrion inner membrane and Nucleus. Translocated into the nucleus by an unknown mechanism. - Information by UniProt
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Database links
- Entrez Gene: 55486 Human
- Entrez Gene: 381038 Mouse
- Entrez Gene: 287979 Rat
- Omim: 607858 Human
- SwissProt: Q9H300 Human
- SwissProt: Q5XJY4 Mouse
- SwissProt: Q3B8P0 Rat
- Unigene: 478469 Human
see all -
Alternative names
- Mitochondrial intramembrane cleaving protease PARL antibody
- Mitochondrial intramembrane-cleaving protease PARL antibody
- P-beta antibody
see all
Images
Protocols
Datasheets and documents
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Datasheet download
References (0)
ab118554 has not yet been referenced specifically in any publications.