Overview

  • Product nameAnti-PARL antibody
    See all PARL primary antibodies
  • Description
    Rabbit polyclonal to PARL
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide containing 15 amino acids from the N-terminal region of Human PARL (NP_061092.3).

  • Positive control
    • Human pancreas tissue; 3T3 cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab118554 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 42 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • FunctionRequired for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
  • Sequence similaritiesBelongs to the peptidase S54 family.
  • Post-translational
    modifications
    P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated.
  • Cellular localizationMitochondrion inner membrane and Nucleus. Translocated into the nucleus by an unknown mechanism.
  • Information by UniProt
  • Database links
  • Alternative names
    • Mitochondrial intramembrane cleaving protease PARL antibody
    • Mitochondrial intramembrane-cleaving protease PARL antibody
    • P-beta antibody
    • parl antibody
    • PARL_HUMAN antibody
    • Pbeta antibody
    • presenilin associated rhomboid-like antibody
    • Presenilins associated rhomboid-like protein antibody
    • PRO2207 antibody
    • PSARL antibody
    • PSARL1 antibody
    • PSENIP2 antibody
    • RHBDS1 antibody
    • Rhomboid 7 homolog 1 antibody
    see all

Anti-PARL antibody images

  • ab118554 at 5µg/ml staining PARL in Formalin-Fixed, Paraffin-Embedded Human pancreas tissue by immunohistochemistry.
  • Lane 1 : Anti-PARL antibody (ab118554) at 1 µg/ml
    Lane 2 : Anti-PARL antibody (ab118554) at 2 µg/ml

    Lane 1 : 3T3 cell lysate
    Lane 2 : 3T3 cell lysate


    Predicted band size : 42 kDa

References for Anti-PARL antibody (ab118554)

ab118554 has not yet been referenced specifically in any publications.

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