• Product nameAnti-PARN antibody
    See all PARN primary antibodies
  • Description
    Rabbit polyclonal to PARN
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide: PSVTALTSGF DTPEERYQKL KKHSMDFLLF QFGLCAFKYD HTDSKHVTKS , corresponding to amino acids 38-87 of Human PARN

  • Positive control
    • SP2/0 lysate


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab66623 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 59, 80 kDa (predicted molecular weight: 69 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • Function3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.
  • Tissue specificityUbiquitous.
  • Sequence similaritiesBelongs to the CAF1 family.
    Contains 1 R3H domain.
  • Cellular localizationNucleus. Cytoplasm. Nucleus > nucleolus. Some nuclear fraction is nucleolar.
  • Information by UniProt
  • Database links
  • Alternative names
    • DAN antibody
    • Deadenylating nuclease antibody
    • Deadenylation nuclease antibody
    • PARN antibody
    • PARN_HUMAN antibody
    • Poly A specific ribonuclease antibody
    • Poly(A) specific ribonuclease antibody
    • Poly(A)-specific ribonuclease PARN antibody
    • Polyadenylate specific ribonuclease antibody
    • Polyadenylate-specific ribonuclease antibody
    see all

Anti-PARN antibody images

  • Anti-PARN antibody (ab66623) at 1.25 µg/ml + SP2/0 lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 69 kDa
    Observed band size : 59,80 kDa (why is the actual band size different from the predicted?)

References for Anti-PARN antibody (ab66623)

ab66623 has not yet been referenced specifically in any publications.

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