Anti-PARP9 antibody - C-terminal (ab170481)

Overview

  • Product name
    Anti-PARP9 antibody - C-terminal
    See all PARP9 primary antibodies
  • Description
    Rabbit polyclonal to PARP9 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide within Mouse PARP9 aa 569-601 (C terminal). The exact sequence is proprietary.
    Database link: Q8CAS9

  • Positive control
    • Mouse lung tissue lysates, formalin fixed and paraffin embedded Human lymphoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab170481 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 97 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Involved in inducing the expression of IFN-gamma-responsive genes.
  • Tissue specificity
    Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form. Most abundantly expressed in lymphomas with a brisk host inflammatory response. In diffuse large B-cell lymphomas tumors, expressed specifically by malignant B-cells.
  • Involvement in disease
    Note=Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors.
  • Sequence similarities
    Contains 2 Macro domains.
    Contains 1 PARP catalytic domain.
  • Cellular localization
    Cytoplasm > cytosol. Nucleus. Shuttles between the nucleus and the cytosol. Export to the cytosol depends on the interaction with DTX3L.
  • Information by UniProt
  • Database links
  • Alternative names
    • ADP-ribosyltransferase diphtheria toxin-like 9 antibody
    • ARTD9 antibody
    • AW214463 antibody
    • B aggressive lymphoma protein antibody
    • Bagl antibody
    • BAL antibody
    • BAL1 antibody
    • BC003281 antibody
    • DKFZp666B0810 antibody
    • DKFZp686M15238 antibody
    • EC 2.4.2.30 antibody
    • FLJ26637 antibody
    • FLJ35310 antibody
    • FLJ41418 antibody
    • FLJ43593 antibody
    • MGC:7868 antibody
    • MGC156739 antibody
    • MGC7868 antibody
    • OTTMUSP00000028034 antibody
    • PARP 9 antibody
    • PARP-9 antibody
    • Parp9 antibody
    • PARP9_HUMAN antibody
    • Poly (ADP ribose) polymerase family member 9 antibody
    • Poly [ADP-ribose] polymerase 9 antibody
    • RGD1307534 antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed and paraffin embedded Human lymphoma labeling PARP9 with ab170481 at 1/50 dilution, followed by peroxidase conjugation of the secondary antibody and DAB staining

  • Anti-PARP9 antibody - C-terminal (ab170481) at 1/100 dilution + mouse lung tissue lysate at 35 µg

    Predicted band size: 97 kDa

References

ab170481 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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