Overview

  • Product nameParthenolide
  • Description
    Lactone derived from Tanacetum parthenium. Anti-inflammatory agent.
  • Biological descriptionLactone derived from Tanacetum parthenium. Anti-inflammatory agent. Inhibits NF-κB indirectly by inhibiting IκB and directly by modifying p65. Additionally induces apoptosis and shows antitumor and antiangiogenic effects. Active in vivo.
  • Purity> 95%

Properties

  • Chemical name(1aR,4E,7aS,10aS,10bR)-2,3,6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methylene-oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
  • Molecular weight248.32
  • Chemical structureChemical Structure
  • Molecular formulaC15H20O3
  • CAS Number20554-84-1
  • PubChem identifier6473881
  • Storage instructionsStore at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C
  • Source

    Tanacetum parthenium

  • Research areas

    References for Parthenolide (ab120849)

    This product has been referenced in:
    • Kim IH  et al. Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model. Exp Mol Med 44:448-56 (2012). Read more (PubMed: 22581380) »
    • Kim SL  et al. Parthenolide suppresses tumor growth in a xenograft model of colorectal cancer cells by inducing mitochondrial dysfunction and apoptosis. Int J Oncol : (2012). Read more (PubMed: 22895542) »
    • Nakabayashi H & Shimizu K Involvement of Akt/NF-?B pathway in antitumor effects of parthenolide on glioblastoma cells in vitro and in vivo. BMC Cancer 12:453 (2012). Read more (PubMed: 23039130) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120849.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"