Lactone derived from Tanacetum parthenium. Anti-inflammatory agent.
Biological descriptionLactone derived from Tanacetum parthenium. Anti-inflammatory agent. Inhibits NF-κB indirectly by inhibiting IκB and directly by modifying p65. Additionally induces apoptosis and shows antitumor and antiangiogenic effects. Active in vivo.
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 75 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Kim IH et al. Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model. Exp Mol Med44:448-56 (2012).
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Kim SL et al. Parthenolide suppresses tumor growth in a xenograft model of colorectal cancer cells by inducing mitochondrial dysfunction and apoptosis. Int J Oncol : (2012).
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Nakabayashi H & Shimizu K Involvement of Akt/NF-?B pathway in antitumor effects of parthenolide on glioblastoma cells in vitro and in vivo. BMC Cancer12:453 (2012).
Read more (PubMed: 23039130) »