All tags Cancer MAPK-ERK1/2 pathway

MAPK-ERK1/2 pathway

Mitogen-activated protein (MAP) kinase pathways are evolutionarily conserved, through which extracellular signals are processed into intracellular responses. This pathway presents the role of MAPK-ERK1/2 in the regulation of cell growth and cell cycle progression.

ERK1 and ERK2 are activated in response to various mitogenic factors, differentiation stimuli and cytokines. ERK1/2 signaling play a critical role in cell proliferation by regulating cell growth and cell cycle progression.  Under certain conditions, ERK1/2 can also have pro-apoptotic functions which has lead this pathway to receive significant attention for development of cancer therapies.

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