All tags NF-kB NF-κB signaling pathway

NF-κB signaling pathway

Review the pathways that result in canonical and non-canonical NF-κB activation and downstream gene expression. ​

​​​​​NF-κB (nuclear factor kappa-light-chain-enhancer of B cells) is a transcription factor that regulates expression of cytokines, growth factors, apoptosis inhibitors and effector enzyme in response to extracellular signals. NF-κB is composed of multiple subunits: RelA (p65), RelB, c-Rel, NF-κB1 (p50) and NF-κB2 (p52). 


NF-κB exists freely in the cytoplasm, where it is inhibited by IκB proteins. In the canonical pathway, NF-κB activation occurs through the phosphorylation, ubiquitination and subsequent proteosomal degradation of IκB. 

Non-cononical activation involves phosphorylation and processing of the p52 precursor, p100 into the mature protein and subsequent nuclear translocation of the RelB:p52 heterodimer.
NF-κB exists freely in the cytoplasm, where it is inhibited by IκB proteins. In the canonical pathway, NF-κB activation occurs through the phosphorylation, ubiquitination and subsequent proteosomal degradation of IκB. 

Non-cononical activation involves phosphorylation and processing of the p52 precursor, p100 into the mature protein and subsequent nuclear translocation of the RelB:p52 heterodimer.