Overview

  • Product name
  • Description
    Goat polyclonal to PAX5
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide: DLEKNYPTPRTSR, corresponding to N terminal amino acids 2-14 of Human PAX5.

  • Positive control
    • U937 lysate
  • General notes
    Principal Names – PAX5; BSAP; paired box gene 5 (B-cell lineage specific activator protein); B-cell lineage specific activator protein; paired box homeotic gene 5 (B-cell lineage specific activator protein) Official Gene Symbol - PAX5 GenBank Accession Number – NP_057953 LocusLink ID - 5079 (human) Gene Ontology terms - transcription activating factor; humoral immune response; histogenesis and organogenesis; development; oncogenesis; transcription from Pol II promoter

Properties

Applications

Our Abpromise guarantee covers the use of ab2935 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: Use at a concentration of 2 - 4 µg/ml. Detects a band of approximately 51 kDa in U937 cells (predicted molecular weight: 42 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.
    • Involvement in disease
      A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.
      Leukemia, acute lymphoblastic, 3
    • Sequence similarities
      Contains 1 paired domain.
    • Developmental stage
      Expressed at early B-cell differentiation, in the developing CNS and in adult testis.
    • Post-translational
      modifications
      O-glycosylated.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • B cell lineage specific activator antibody
      • B cell lineage specific activator protein antibody
      • B cell specific activator protein antibody
      • B cell specific transcription factor antibody
      • B-cell-specific transcription factor antibody
      • BSAP antibody
      • EBB-1 antibody
      • KLP antibody
      • Paired box 5 antibody
      • Paired box gene 5 (B cell lineage specific activator protein) antibody
      • Paired box gene 5 (B cell lineage specific activator) antibody
      • Paired box gene 5 antibody
      • Paired box homeotic gene 5 antibody
      • Paired box protein Pax 5 antibody
      • Paired box protein Pax-5 antibody
      • Paired domain gene 5 antibody
      • PAX 5 antibody
      • PAX5 antibody
      • PAX5_HUMAN antibody
      • Transcription factor PAX 5 antibody
      see all

    Images



    • Predicted band size : 42 kDa


      ab2935 staining (3µg/ml) of U937 lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

    References

    This product has been referenced in:
    • Shein Idelson M  et al. Innate synchronous oscillations in freely-organized small neuronal circuits. PLoS One 5:e14443 (2010). ICC . Read more (PubMed: 21203438) »

    See 1 Publication for this product

    Customer reviews and Q&As

    Thank you for your patience. I am sorry to hear that you are experiencing difficulties with this product ab2935 in immunohistochemistry. Often it is possible to make suggestions that help resolve problems. We will happily offer technical support bu...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up