Anti-PAX8 antibody [BC12] (ab124445)
Key features and details
- Mouse monoclonal [BC12] to PAX8
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-PAX8 antibody [BC12]
See all PAX8 primary antibodies -
Description
Mouse monoclonal [BC12] to PAX8 -
Host species
Mouse -
Specificity
ab124445 does not stain B-cells, and does not recognize epitopes of pancreatic origin and neuroendocrine cells in stomach and colon. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein corresponding to Human PAX8.
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Epitope
The epitope maps sequence as 258 to 272. -
Positive control
- IHC-P Human renal tissue and renal carcinoma tissue.
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General notes
Make dilutions in Renoir Red diluent.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.09% Sodium azide
Constituents: 97.5% Water, 0.99% BSA, 0.33% Tris HCl, 0.04% Tween, 0.007% Hydrochloric acid
Buffer contains protein carrier. -
Concentration information loading...
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Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
BC12 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab124445 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use at an assay dependent concentration.
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Notes |
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IHC-P
Use at an assay dependent concentration. |
Target
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Function
Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. -
Tissue specificity
Expressed in the excretory system, thyroid gland and Wilms tumors. -
Involvement in disease
Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue. -
Sequence similarities
Contains 1 paired domain. -
Developmental stage
In developing excretory system, during thyroid differentiation and in adult thyroid. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 7849 Human
- Omim: 167415 Human
- SwissProt: Q06710 Human
- Unigene: 469728 Human
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Alternative names
- OTTHUMP00000158659 antibody
- OTTHUMP00000158660 antibody
- OTTHUMP00000203723 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab124445 has not yet been referenced specifically in any publications.