General notesab94211 is a 293T cell transfected lysate in which Human PBR has been transiently over-expressed using a pCMV-PBR plasmid. The lysate is provided in 1X Sample Buffer.
Note: For more details about how the transfected lysate was prepared view preparation notes
BackgroundFunction: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells.
Tissue specificity: Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.
Similarity: Belongs to the TspO/BZRP family.