Anti-PBX1 antibody [146C1a] (ab66496)

Overview

  • Product name
    Anti-PBX1 antibody [146C1a]
    See all PBX1 primary antibodies
  • Description
    Mouse monoclonal [146C1a] to PBX1
  • Tested applications
    Suitable for: WB, Dot blotmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment from the internal region of human PBX1

Properties

Applications

Our Abpromise guarantee covers the use of ab66496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 47 kDa.
Dot blot Use at an assay dependent dilution.

Target

  • Function
    Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation.
  • Tissue specificity
    Expressed in all tissues except in cells of the B and T lineage.
  • Involvement in disease
    Note=A chromosomal aberration involving PBX1 is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with TCF3. E2A-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family.
  • Sequence similarities
    Belongs to the TALE/PBX homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp686B09108 antibody
    • Homeo box protein PBX1 antibody
    • Homeo box protein PRL antibody
    • Homeobox protein PBX 1 antibody
    • Homeobox protein PBX1 antibody
    • Homeobox protein PRL antibody
    • MGC126627 antibody
    • PBX 1 antibody
    • Pbx1 antibody
    • PBX1_HUMAN antibody
    • Pre B cell leukemia homeobox 1 antibody
    • Pre B cell leukemia transcription factor 1 antibody
    • Pre-B-cell leukemia transcription factor 1 antibody
    • PRL antibody
    see all

Images

References

ab66496 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for your email last week and for your patience. I have heard back from the testing laboratory, and unfortunately the antibody has not been specifically tested against the isoform B. However, we do have a PBX1 antibody that I would expect to r...

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