Anti-PC1/3 antibody [3D2] (ab117735)


  • Product nameAnti-PC1/3 antibody [3D2]
    See all PC1/3 primary antibodies
  • Description
    Mouse monoclonal [3D2] to PC1/3
  • Tested applicationsSuitable for: WB, Sandwich ELISA, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant protein of Human PC1/3 protein (NP_000430.3).

  • Positive control
    • PC12 and NIH3T3 cell lysates; Human Brain, cortex tissue; HeLa cells; recombinant PC1/3 protein.



Our Abpromise guarantee covers the use of ab117735 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 84 kDa.
Sandwich ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Steam slides in 0.01 M sodium citrate buffer, pH 6.0 at 99-100°C - 20 minutes. Remove from heat and let stand at room temperature in buffer - 20 minutes. Rinse in 1X TBS with Tween (TBST) for 1 minute @ RT and proceed with staining.
ICC/IF Use a concentration of 30 µg/ml.


  • FunctionInvolved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.
  • Involvement in diseaseDefects in PCSK1 are the cause of proprotein convertase 1 deficiency (PC1 deficiency) [MIM:600955]. PC1 deficiency is characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction It is due to impaired processing of prohormones.
  • Sequence similaritiesBelongs to the peptidase S8 family. Furin subfamily.
  • Cellular localizationCytoplasmic vesicle > secretory vesicle. Localized in the secretion granules.
  • Information by UniProt
  • Database links
  • Alternative names
    • BDP antibody
    • NEC 1 antibody
    • NEC1 antibody
    • NEC1_HUMAN antibody
    • Neuroendocrine convertase 1 antibody
    • PC1 antibody
    • PC3 antibody
    • PCSK1 antibody
    • Prohormone convertase 1 antibody
    • Prohormone convertase 1/3 antibody
    • Prohormone convertase 3 antibody
    • Proprotein convertase 1 antibody
    • SPC3 antibody
    see all

Anti-PC1/3 antibody [3D2] images

  • Anti-PC1/3 antibody [3D2] (ab117735) + PC12 cell lysate

    Predicted band size : 84 kDa
  • Anti-PC1/3 antibody [3D2] (ab117735) + NIH3T3 cell lysate

    Predicted band size : 84 kDa
  • ab117735, at 10 µg/ml, staining PC1/3 in Formalin-fixed, Paraffin-embedded Human Brain cortex tissue by Immunohistochemistry.
  • ab117735 at 30µg/ml dilution staining PC1/3 in HeLa cells by Immunofluorescence.
  • Detection limit for recombinant tagged PC1/3 is approximately 0.03ng/ml (ab117735) as a capture antibody.

References for Anti-PC1/3 antibody [3D2] (ab117735)

ab117735 has not yet been referenced specifically in any publications.

Product Wall

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