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Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> Translation >> ER Translocation
Overview
Product name
Anti-PC6 antibody - Aminoterminal end
See all PC6 products (2) ...
Description
Rabbit polyclonal to PC6 - Aminoterminal end
Specificity
ab39873 recognizes the Amino end of the mature enzyme subtilisin like serine protease PC6.
Tested applications
IHC-P, WBmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide corresponding to the amino end of mature Human PC6.
(Peptide available as ab41413.)
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol, PBS, 500mM Sodium chloride, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Applications
Show applications key
Our Abpromise guarantee covers the use of ab39873 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P
WB
Application notes
IHC-P: 1/500 (PMID 19339735).
WB: 1/1000 - 1/5000. Predicted molecular weight: 101 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif.
Tissue specificity
Expressed in T-lymphocytes.
Sequence similarities
Belongs to the peptidase S8 family.
Contains 1 homo B/P domain.
Contains 1 PLAC domain.
Domain
The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.
Cellular localization
Secreted.
Target information above from: UniProt accessionQ92824
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- FLJ11149 antibody
- FLJ16215 antibody
- hPC6 antibody
see all
Database links
- Entrez Gene: 5125 Human
- Entrez Gene: 18552 Mouse
- Entrez Gene: 116548 Rat
- Omim: 600488 Human
- SwissProt: Q92824 Human
- SwissProt: Q04592 Mouse
- SwissProt: P41413 Rat
- Unigene: 368542 Human
see all
Protocols
References for Anti-PC6 antibody - Aminoterminal end (ab39873)
This product has been referenced in:
- Fuller JAet al. Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head. Invest Ophthalmol Vis Sci 50:5759-68 (2009). IHC-P; Human.Read more (PubMed: 19339735) »
See 1 publication for this product
Publishing research using ab39873? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"