Overview

  • Product name
    Anti-PCBP2/hnRNP E2 antibody
    See all PCBP2/hnRNP E2 primary antibodies
  • Description
    Rabbit polyclonal to PCBP2/hnRNP E2
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide containing a sequence corresponding to a region within amino acids 299-362 (IIGRQGAKIN EIRQMSGAQI KIANPVEGST DRQVTITGSA ASISLAQYLI NVRLSSETGG MGSS) of Human PCBP2/hnRNP E2 (NP_114366).

  • Positive control
    • HepG2 whole cell lysate; HeLa cells; 293T, A431, H1299, and Raji cells

Properties

Applications

Our Abpromise guarantee covers the use of ab95942 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 39 kDa.
ICC/IF 1/100 - 1/200.

Target

  • Function
    Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation.
  • Tissue specificity
    Detected in all tissues examined.
  • Sequence similarities
    Contains 3 KH domains.
  • Post-translational
    modifications
    Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.
  • Cellular localization
    Nucleus. Cytoplasm. Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alpha CP2 antibody
    • Alpha-CP2 antibody
    • alphaCP-2 antibody
    • Cbp antibody
    • CTBP antibody
    • Heterogeneous nuclear ribonucleoprotein E2 antibody
    • Heterogenous nuclear ribonucleoprotein E2 antibody
    • hnRNP E2 antibody
    • hnRNP-E2 antibody
    • HNRNPE2 antibody
    • Hnrnpx antibody
    • HNRPE2 antibody
    • Hnrpx antibody
    • MGC110998 antibody
    • PCBP2 antibody
    • PCBP2_HUMAN antibody
    • poly(rC) binding protein 2 antibody
    • Poly(rC)-binding protein 2 antibody
    • Putative heterogeneous nuclear ribonucleoprotein X antibody
    • rCbinding protein 2 antibody
    see all

Images

  • Anti-PCBP2/hnRNP E2 antibody (ab95942) at 1/500 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 39 kDa
  • ab95942, at 1/200 dilution, staining PCBP2/hnRNP E2 in paraformaldehyde-fixed HeLa cells by Immunofluorescence. Right image is merged with DNA probe.

References

ab95942 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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