Synthetic peptide containing a sequence corresponding to a region within amino acids 299-362 (IIGRQGAKIN EIRQMSGAQI KIANPVEGST DRQVTITGSA ASISLAQYLI NVRLSSETGG MGSS) of Human PCBP2/hnRNP E2 (NP_114366).
FunctionSingle-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation.
Tissue specificityDetected in all tissues examined.
Sequence similaritiesContains 3 KH domains.
Post-translational modificationsPhosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.
Cellular localizationNucleus. Cytoplasm. Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.