Overview

  • Product nameAnti-PCCB antibody
    See all PCCB primary antibodies
  • Description
    Rabbit polyclonal to PCCB
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Caenorhabditis elegans, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 396-445 (GFLPGTAQEY GGIIRHGAKL LYAFAEATVP KVTVITRKAY GGAYDVMSSK) of Human PCCB (NP_000523).

  • Positive control
    • Human fetal brain lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab90699 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 58 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • PathwayMetabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.
  • Involvement in diseaseDefects in PCCB are the cause of propionic acidemia type II (PA-2) [MIM:606054]. PA-2 is a life-threatening disease characterized by episodic vomiting, lethargy and ketosis, neutropenia, periodic thrombocytopenia, hypogammaglobulinemia, developmental retardation, and intolerance to protein.
  • Sequence similaritiesBelongs to the AccD/PCCB family.
    Contains 1 carboxyltransferase domain.
  • Cellular localizationMitochondrion matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp451E113 antibody
    • PCCase subunit beta antibody
    • pccB antibody
    • PCCB_HUMAN antibody
    • pccBC Complementation group antibody
    • Propanoyl CoA:carbon dioxide ligase subunit beta antibody
    • Propanoyl-CoA:carbon dioxide ligase subunit beta antibody
    • Propionyl CoA carboxylase beta chain, mitochondrial antibody
    • propionyl Coenzyme A carboxylase, beta polypeptide antibody
    • Propionyl-CoA carboxylase , beta subunit antibody
    • Propionyl-CoA carboxylase beta chain, mitochondrial antibody
    • R74805 antibody
    see all

Anti-PCCB antibody images

  • Anti-PCCB antibody (ab90699) at 1 µg/ml (5% skim milk / PBS buffer, and ) + Human fetal brain lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/5000 dilution

    Predicted band size : 58 kDa

References for Anti-PCCB antibody (ab90699)

ab90699 has not yet been referenced specifically in any publications.

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