Overview

  • Product nameAnti-PCSK9 antibody
    See all PCSK9 primary antibodies
  • Description
    Rabbit polyclonal to PCSK9
  • Tested applicationsSuitable for: ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Chimpanzee, Macaque Monkey, Gorilla, Marmoset (common)
  • Immunogen

    Synthetic peptide from Mouse PCSK9 amino acids 152-163

    VFAQSIPWNLER

  • Positive control
    • HepG2 cells

Properties

Applications

Our Abpromise guarantee covers the use of ab95478 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/50.
WB Use at an assay dependent dilution. Predicted molecular weight: 74 kDa.

Target

  • FunctionMay be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
  • Tissue specificityExpressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
  • Involvement in diseaseDefects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.
  • Sequence similaritiesBelongs to the peptidase S8 family.
    Contains 1 peptidase S8 domain.
  • Post-translational
    modifications
    The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Convertase subtilisin/kexin type 9 preproprotein antibody
    • FH3 antibody
    • HCHOLA3 antibody
    • Hypercholesterolemia autosomal dominant 3 antibody
    • LDLCQ1 antibody
    • NARC 1 antibody
    • NARC-1 antibody
    • NARC1 antibody
    • Neural apoptosis regulated convertase 1 antibody
    • Neural apoptosis-regulated convertase 1 antibody
    • PC 9 antibody
    • PC9 antibody
    • PCSK 9 antibody
    • PCSK9 antibody
    • PCSK9_HUMAN antibody
    • Proprotein convertase 9 antibody
    • Proprotein convertase PC9 antibody
    • Proprotein convertase subtilisin/kexin type 9 antibody
    • PSEC0052 antibody
    • Subtilisin/kexin like protease PC9 antibody
    • Subtilisin/kexin-like protease PC9 antibody
    see all

Anti-PCSK9 antibody images

  • ab95478 staining PCSK9 in HepG2 cells by immunofluorescence. The positive staining cytoplasm was visualized in red with a Cy3 conjugated goat anti-rabbit secondary antibody.

References for Anti-PCSK9 antibody (ab95478)

ab95478 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab95478.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"