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Goat polyclonal to PCSK9 - BSA free
, corresponding to C terminal amino acids 679-692 of Human PCSK9
- Human liver, pancreas and adipose lysates.
Shipped at 4°C. Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
Preservative: 0.02% Sodium azide
Concentration information loading...
Immunogen affinity purified
was purified from goat serum by ammonium sulphate precipitation prior to immunogen affinity chromatography.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
||Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 74 kDa.
||Use a concentration of 2 - 6 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
||Use a concentration of 5 µg/ml.
May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
Involvement in disease
Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.
Belongs to the peptidase S8 family.
Contains 1 peptidase S8 domain.
The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.
Information by UniProt
- Convertase subtilisin/kexin type 9 preproprotein antibody
- FH3 antibody
- HCHOLA3 antibody
has not yet been referenced specifically in any publications.
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