PCSK9 antibody - Homo-B domain (ab42086)

Product Name 

PCSK9 antibody - Homo-B domain

Product type 

Primary antibodies

Description 

Rabbit polyclonal to PCSK9 - Homo-B domain

Immunogen 

Synthetic peptide corresponding to the CT (Homo-B like) domain of human PCSK9.

(Peptide available as ab44583.)

Reacts with 
(species key)

Hu

Specificity 

This antibody recognizes both forms of PCSK9 in the region corresponding to the CT (Homo-B like) domain.

We have a range of domain specific antibodies for this target. For a full list please see all PCSK9 antibodies

Tested applications 
(see key)

WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
WB: 1/1000 - 1/5000. Predicted molecular weight: 74 kDa. Recommended starting dilution 1/1000 with colourimetrtic substrates, 1/5000 with chemiluminescent substrates. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user. The 692 amino acid form has a predicted mass of 74.49 kDa, and a pI of 6.09, but glycosylation and other post-translational modifications make the pre-pro PC9 run at 78-80 kDa, the mature PC9 at 58 kDa

Cellular localization 

Secreted

Research areas 

Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Proprotein Convertases
Signal Transduction >> Metabolism >> Lipid metabolism
Stem Cells >> Neural Stem Cells >> Intracellular
Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cholesterol Metabolism
Signal Transduction >> Metabolism >> Amino Acids

Relevance 

PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. PCSK9 may function as a proprotein convertase. PCSK9 plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in PCSK9 gene have been associated with a third form of autosomal dominant familial hypercholesterolemia.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol, PBS, 0.5M Sodium chloride

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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