Overview

  • Product name
    PD 168077 maleate
  • Description
    Potent, selective D4 agonist
  • Biological description
    Potent, selective D4 dopamine receptor agonist. Displays >400-fold selectivity over D2 and >300-fold selectivity over D3 subtypes (Ki values are 11.9, 2540, and 1050 nM for D4, D3, and D2 receptors, respectively). Reverses object recognition deficits.
  • Purity
    > 98%
  • General notes

    This product appears to be unstable in ethanol solution

Properties

  • Chemical name
    N-[4-(2-Cyanophenyl)-1-piperazinyl]methyl-3-methylbenzamide maleate
  • Molecular weight
    450.49
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C20H22N4O.C4H4O4
  • CAS Number
    190383-31-4
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Sood P  et al. PD168077, a D(4) receptor agonist, reverses object recognition deficits in rats: potential role for D(4) receptor mechanisms in improving cognitive dysfunction in schizophrenia. J Psychopharmacol 25:792-800 (2011). Read more (PubMed: 21088042) »
  • Basso AM  et al. Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test. Neuropsychopharmacology 30:1257-68 (2005). Read more (PubMed: 15688083) »
  • Nayak S & Cassaday HJ The novel dopamine D4 receptor agonist (PD 168,077 maleate): doses with different effects on locomotor activity are without effect in classical conditioning. Prog Neuropsychopharmacol Biol Psychiatry 27:441-9 (2003). Read more (PubMed: 12691779) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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