PD 184352 (CI-1040) (DMSO solution) (ab146601)

Overview

  • Product name
    PD 184352 (CI-1040) (DMSO solution)
  • Description
    Potent, highly selective ATP non-competitive MEK1/2 inhibitor
  • Biological description
    Potent, highly selective ATP non-competitive MEK1/2 inhibitor. Enhances cisplatin (ab141398) dependent apoptosis. Shows antitumor effects in vivo. Orally active.

    Also available as a solid (ab141348).
  • Purity
    > 99%

Properties

  • Chemical name
    2-(2-Chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
  • Molecular weight
    478.67
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C17H14ClF2IN2O2
  • CAS Number
    212631-79-3
  • PubChem identifier
    6918454
  • Storage instructions
    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview
    Supplied in DMSO (10 mM)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    c1cc(c(cc1I)Cl)Nc2c(ccc(c2F)F)C(=O)NOCC3CC3
  • Source

    Synthetic

References

ab146601 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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