Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence

    Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab173374 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Blocking - Blocking peptide for Anti-PD1 antibody [EPR4877(2)] (ab137132)

    • Form
      Liquid
    • Additional notes

      - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
      - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
      - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
      - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
      - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at -20°C.

    General Info

    • Alternative names
      • CD279
      • CD279 antigen
      • hPD 1
      • hPD l
      • hPD-1
      • hSLE1
      • PD 1
      • PD-1
      • PD1
      • PDCD 1
      • PDCD1
      • PDCD1_HUMAN
      • Programmed cell death 1
      • Programmed cell death 1 protein
      • Programmed cell death protein 1
      • Protein PD 1
      • Protein PD-1
      • SLEB2
      • Systemic lupus erythematosus susceptibility 2
      see all
    • Function
      Possible cell death inducer, in association with other factors.
    • Involvement in disease
      Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
    • Sequence similarities
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • Developmental stage
      Induced at programmed cell death.
    • Cellular localization
      Membrane.
    • Information by UniProt

    References

    ab173374 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    I wanted to inform you that we have now added the blocking peptide for ab137132 Anti-PD1 antibody [EPR4877(2)]. This peptide, catalog number ab173374, may be found at: http://www.abcam.com/ab173374.html

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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