Overview

  • Product nameAnti-PDCD10 antibody
    See all PDCD10 primary antibodies
  • Description
    Rabbit polyclonal to PDCD10
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Highly pure (>95%) recombinant Human PDCD10 (Met1-Ala212) derived from E. coli fused to a N-terminal His-tag. (NM_007217.3).

  • General notesEndotoxin level: < 0.1 EU/1µg of the antibody (LAL).

Properties

Applications

Our Abpromise guarantee covers the use of ab111507 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 25 kDa.
ICC/IF Use a concentration of 2 - 10 µg/ml.

Target

  • FunctionPromotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development.
  • Tissue specificityUbiquitous.
  • Involvement in diseaseDefects in PDCD10 are the cause of cerebral cavernous malformations type 3 (CCM3) [MIM:603285]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and usually present clinically during the 3rd to 5th decade of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.
  • Sequence similaritiesBelongs to the PDCD10 family.
  • Cellular localizationCytoplasm. Golgi apparatus membrane. Cell membrane. Partially co-localizes with endogenous PXN at the leading edges of migrating cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • Apoptosis related protein 15 antibody
    • CCM3 antibody
    • Cerebral cavernous malformations 3 protein antibody
    • MGC1212 antibody
    • MGC24477 antibody
    • PDC10_HUMAN antibody
    • PDCD 10 antibody
    • PDCD10 antibody
    • Programmed cell death 10 antibody
    • Programmed cell death protein 10 antibody
    • TF 1 cell apoptosis related protein 15 antibody
    • TF-1 cell apoptosis-related protein 15 antibody
    • TFAR15 antibody
    see all

References for Anti-PDCD10 antibody (ab111507)

ab111507 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"