• Product nameAnti-PDE11A antibody
    See all PDE11A primary antibodies
  • Description
    Rabbit polyclonal to PDE11A
  • SpecificityThis antibody does not cross-react with any of the members of the PDE family tested so far.
  • Tested applicationsSuitable for: WB, IP, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to C terminal amino acids 454-468 of Human PDE11A.

  • Positive control
    • Rat testis, skeletal muscle, kidney and brain.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer'Stabilization buffer' with 0.02% thimerosal or merthiolate.
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab14624 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Detects a band of approximately 57, 65, 95 kDa (predicted molecular weight: 105 kDa).
IP 1/250.
IHC-P Use at an assay dependent concentration.


  • FunctionPlays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
  • Tissue specificityIsoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.
  • Involvement in diseaseDefects in PDE11A are the cause of primary pigmented nodular adrenocortical disease type 2 (PPNAD2) [MIM:610475]. Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. PPNAD2 is characterized by adrenal glands with overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. PPNAD2 leads to Cushing syndrome.
  • Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • DomainThe tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP leading to stimulate the enzyme activity.
  • Cellular localizationCytoplasm > cytosol.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5''-cyclic-AMP and -GMP phosphodiesterase 11A antibody
    • cAMP and cGMP phosphodiesterase 11A antibody
    • cGMP phosphodiesterase 11A antibody
    • Cyclic nucleotide phosphodiesterase 11A antibody
    • Dual 3'' antibody
    • Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A antibody
    • pde11 antibody
    • PDE11_HUMAN antibody
    • pde11a antibody
    • PDE11A1 antibody
    • pde11a2 antibody
    • Phosphodiesterase 11A antibody
    • PPNAD2 antibody
    see all

References for Anti-PDE11A antibody (ab14624)

This product has been referenced in:
  • Vezzosi D  et al. Phosphodiesterase 11A (PDE11A) gene defects in patients with acth-independent macronodular adrenal hyperplasia (AIMAH): functional variants may contribute to genetic susceptibility of bilateral adrenal tumors. J Clin Endocrinol Metab 97:E2063-9 (2012). WB ; Human . Read more (PubMed: 22996146) »
  • Kelly MP  et al. Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proc Natl Acad Sci U S A 107:8457-62 (2010). WB ; Mouse . Read more (PubMed: 20404172) »

See all 6 Publications for this product

Product Wall

Thank you for your enquiry. We do not have any references available for the use of Ab14624 in IHC. To our knowledge, this antibody has yet to be tested in this application. All tested applications are specified on Abcam product datasheets. Sinc...

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