• Product nameAnti-PDE11A antibody
    See all PDE11A primary antibodies
  • Description
    Rabbit polyclonal to PDE11A
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide corresponding to Human PDE11A (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH).

  • Positive control
    • Human Testis tissue.
  • General notesFor short term storage: -4°C


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.1% Sodium Azide
    Constituents: PBS, pH 7.7
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products


Our Abpromise guarantee covers the use of ab61822 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.


  • FunctionPlays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
  • Tissue specificityIsoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.
  • Involvement in diseaseDefects in PDE11A are the cause of primary pigmented nodular adrenocortical disease type 2 (PPNAD2) [MIM:610475]. Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. PPNAD2 is characterized by adrenal glands with overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. PPNAD2 leads to Cushing syndrome.
  • Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • DomainThe tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP leading to stimulate the enzyme activity.
  • Cellular localizationCytoplasm > cytosol.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5''-cyclic-AMP and -GMP phosphodiesterase 11A antibody
    • cAMP and cGMP phosphodiesterase 11A antibody
    • cGMP phosphodiesterase 11A antibody
    • Cyclic nucleotide phosphodiesterase 11A antibody
    • Dual 3'' antibody
    • Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A antibody
    • pde11 antibody
    • PDE11_HUMAN antibody
    • pde11a antibody
    • PDE11A1 antibody
    • pde11a2 antibody
    • Phosphodiesterase 11A antibody
    • PPNAD2 antibody
    see all

Anti-PDE11A antibody images

  • ab61822, at 5µg/ml, staining human PDE11A in testis by immunohistochemistry. Formalin-fixed paraffin-embedded tissue.

References for Anti-PDE11A antibody (ab61822)

ab61822 has not yet been referenced specifically in any publications.

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