Overview

  • Product nameAnti-PDE12 antibody
    See all PDE12 primary antibodies
  • Description
    Rabbit polyclonal to PDE12
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide corresponding to a region within C terminal amino acids 369-398 of Human PDE12 (NP_808881.3).

  • Positive control
    • MDA-MB231 cell line lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab107000 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 67 kDa.

Target

  • FunctionEnzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Play a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
  • Tissue specificityUbiquitous.
  • Sequence similaritiesBelongs to the CCR4/nocturin family.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2 PDE antibody
    • 2' 5' phosphodiesterase 12 antibody
    • 2' phosphodiesterase antibody
    • 2',5'-phosphodiesterase 12 antibody
    • 2'-PDE antibody
    • 2-PDE antibody
    • 2PDE antibody
    • DKFZp667B1218 antibody
    • Pde12 antibody
    • PDE12_HUMAN antibody
    • Phosphodiesterase 12 antibody
    see all

Anti-PDE12 antibody images

  • Anti-PDE12 antibody (ab107000) at 1/100 dilution + MDA-MB231 cell line lysate at 35 µg

    Predicted band size : 67 kDa

References for Anti-PDE12 antibody (ab107000)

ab107000 has not yet been referenced specifically in any publications.

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