The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/250 - 1/500. Predicted molecular weight: 65 kDa. This antibody labels multiple bands in the 65-72 kDa range all believed to be various PDE1B variants expressed in various rat tissues.
Use at an assay dependent dilution.
FunctionCyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Giachini FR et al. Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1. Hypertension57:655-63 (2011).
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