Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism.
Abundant in adipose tissues.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
Lane 1: Detection of Human PDE3B by Immunoprecipitation from HeLa whole cell lysate (1 mg for IP, 20% of IP loaded), using ab99289 at 3 µg/mg lysate for IP. Lane 2: Immunoprecipitation from HeLa whole cell lysate (1 mg for IP, 20% of IP loaded), using Control IgG. Subsequent Western blot detection used ab99289 at 1 µg/ml. Developed using the ECL technique with an exposure time of 30 seconds.