Anti-PDE4C antibody (ab14608)

Overview

  • Product name
  • Description
    Rabbit polyclonal to PDE4C
  • Specificity
    This antibody detects 3 isoforms of PDE4C subclasses (PDE4C1, PDE4C2 and PDE4C3).
  • Tested applications
    Suitable for: IP, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic cyclic peptide (carboxy-terminal peptide common to all PDE4C proteins).

  • Positive control
    • recombinant protein PDE4C1/2

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Thimerosal / Merthiolate
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab14608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP 1/20.
WB 1/500. Predicted molecular weight: 80 kDa.Can be blocked with PDE4C peptide (ab169990).

Target

  • Function
    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
  • Tissue specificity
    Expressed in various tissues but not in cells of the immune system.
  • Pathway
    Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
  • Sequence similarities
    Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5''-cyclic phosphodiesterase 4C antibody
    • cAMP specific 3' 5' cyclic phosphodiesterase 4C antibody
    • cAMP-specific 3'' antibody
    • DPDE 1 antibody
    • DPDE1 antibody
    • MGC126222 antibody
    • PDE 21 antibody
    • PDE 4C antibody
    • PDE21 antibody
    • Pde4c antibody
    • PDE4C_HUMAN antibody
    • Phosphodiesterase 4C antibody
    • Phosphodiesterase 4C cAMP specific antibody
    • Phosphodiesterase 4C, cAMP specific (phosphodiesterase E1 dunce homolog, Drosophila) antibody
    • Phosphodiesterase E1 dunce homolog antibody
    • Phosphodiesterase E1 dunce homolog Drosophila antibody
    • Phosphodiesterase type 4C antibody
    see all

References

ab14608 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Application
Western blot
Sample
Rat Cell lysate - whole cell (Astrocytes)
Loading amount
40 µg
Specification
Astrocytes
Gel Running Conditions
Reduced Denaturing (12)
Blocking step
BSA as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
Username

Abcam user community

Verified customer

Submitted Jan 24 2013

Thank you for your enquiry. 1) PDE4A antibody (ab14607) does not cross react to any known PDE4 subtype except all the PDE4A subtype variants including PDE4A1, A5, Ax, A8, it has little or no reactivity towards PDE4A10 and PDE4A11. We have tested fo...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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