Overview

  • Product nameAnti-PDE4D7 antibody
  • Description
    Rabbit polyclonal to PDE4D7
  • SpecificityThe antibody does not cross reacts with PDE4D1, D2, D3, D4 and D5 variants. It also does not cross react with PDE4A, PDE4B or PDE4C.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide from unique region near N terminal of the PDE4D7 variant. (Rat)

  • Positive control
    • Rat cortical membranes.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: BSA
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab14629 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200. Detects a band of approximately 110 kDa.

Target

  • RelevanceCyclic AMP dependent phosphodiesterase type D (PDE4D) family is comprised of 5 variants (PDE4D1, D2, D3, D4, D6, D7, and D8; 1, 2). One or more PDE4D subtype variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype variants are expressed in varying ratios, and their activity is regulated in tandem with GPCRs stimulation and selective phosphorylation by PKA and other kinases. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein protein interactions with cytoskeletal scaffolding proteins. Anti PDE4D antibodies are ideal tools for studying regulation, expression, phosphorylation, and protein protein interactions of PDE4D variants employing pull down immunoprecipitation protocol.
  • Database links
  • Alternative names
    • DPDE3 antibody
    • HSPDE4D antibody
    • PDE43 antibody
    • PDE4D antibody
    • Phosphodiesterase 4D antibody
    • Phosphodiesterase 4D cAMP-specific antibody
    see all

Anti-PDE4D7 antibody images

  • Lane 1 : Anti-PDE4D7 antibody (ab14629)
    Lanes 2 - 3 : Anti-PDE4D7 antibody (ab14629) at 1/750 dilution

    Lane 1 : Negative Control
    Lane 2 : Human Rec-PDE4D7 (1 ng)
    Lane 3 : Human Rec-PDE4D7 (10 ng)

References for Anti-PDE4D7 antibody (ab14629)

ab14629 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"