Overview

  • Product nameAnti-PDE5A antibody
    See all PDE5A primary antibodies
  • Description
    Mouse monoclonal to PDE5A
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 29-139 of Human PDE5A

Properties

Applications

Our Abpromise guarantee covers the use of ab56505 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPlays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
    • Tissue specificityExpressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
    • PathwayPurine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.
    • Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family.
      Contains 2 GAF domains.
    • DomainComposed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B.
    • Post-translational
      modifications
      Phosphorylation is regulated by binding of cGMP to the two allosteric sites.
    • Information by UniProt
    • Database links
    • Alternative names
      • 5''-cyclic phosphodiesterase antibody
      • CGB PDE antibody
      • CGB-PDE antibody
      • CGBPDE antibody
      • cGMP binding cGMP specific 3' 5' cyclic nucleotide phosphodiesterase antibody
      • cGMP binding cGMP specific 35 cyclic nucleotide phosphodiesterase antibody
      • cGMP binding cGMP specific phosphodiesterase antibody
      • cGMP binding/cGMP specific phosphodiesterase antibody
      • cGMP specific 3'5' cyclic phosphodiesterase antibody
      • cGMP specific phosphodiesterase PDE5A2 antibody
      • cGMP specific phosphodiesterase type 5A antibody
      • cGMP-binding cGMP-specific phosphodiesterase antibody
      • cGMP-specific 3'' antibody
      • CN5A antibody
      • CN5N antibody
      • PDE 5 antibody
      • PDE 5A antibody
      • PDE5 antibody
      • Pde5a antibody
      • PDE5A_HUMAN antibody
      • PDE5A1 antibody
      • Phosphodiesterase 5A antibody
      • Phosphodiesterase 5A cGMP specific antibody
      • Phosphodiesterase isozyme 5 antibody
      see all

    Anti-PDE5A antibody images

    • Western blot against tagged recombinant protein immunogen using ab56505 PDE5A antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    References for Anti-PDE5A antibody (ab56505)

    ab56505 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"