Overview

  • Product name
    Anti-PDE6H antibody
  • Description
    Rabbit polyclonal to PDE6H
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 4-33 of Human PDE6H (Uniprot: Q13956)

  • Positive control
    • Mouse testis tissue lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab156104 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 9 kDa.

Target

  • Function
    Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
  • Involvement in disease
    Defects in PDE6H are the cause of cone dystrophy retinal type 3A (RCD3A) [MIM:610024]; also known as cone dystrophy with night blindness and supernormal rod responses. RCD3A is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy.
  • Sequence similarities
    Belongs to the rod/cone cGMP-PDE gamma subunit family.
  • Domain
    The C-terminal region is important in conferring inhibition.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5''-cyclic phosphodiesterase subunit gamma antibody
    • CNCG_HUMAN antibody
    • GMP-PDE gamma antibody
    • Pde6h antibody
    • Retinal cone rhodopsin-sensitive cGMP 3'' antibody
    see all

Images

  • Anti-PDE6H antibody (ab156104) at 1/100 dilution + Mouse testis tissue lysate at 35 µg

    Predicted band size: 9 kDa

References

ab156104 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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