Overview

  • Product nameAnti-PDE7A antibody
    See all PDE7A primary antibodies
  • Description
    Rabbit polyclonal to PDE7A
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide.

Properties

Applications

Our Abpromise guarantee covers the use of ab14616 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Detects a band of approximately 53 kDa (predicted molecular weight: 55 kDa).
IP 1/250.

Target

  • FunctionHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
  • Tissue specificityPDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.
  • PathwayPurine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
  • Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.
  • Developmental stageDevelopmentally regulated. PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development. It persists strongly only in adult skeletal muscle.
  • DomainComposed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
  • Cellular localizationCytoplasm > cytosol. PDE7A1 (57 kDa) is located mostly to soluble cellular fractions and Cytoplasm. PDE7A2 (50 kDa) is located to particulate cellular fractions.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5''-cyclic phosphodiesterase 7A antibody
    • HCP 1 antibody
    • HCP1 antibody
    • High affinity cAMP specific 3'5' cyclic phosphodiesterase 7A antibody
    • High affinity cAMP-specific 3'' antibody
    • P2A antibody
    • PDE 7 antibody
    • PDE 7A antibody
    • PDE1/PDE2 yeast human complement of antibody
    • PDE7 antibody
    • PDE71 antibody
    • PDE7A antibody
    • PDE7A_HUMAN antibody
    • Phosphodiesterase 7A antibody
    • Phosphodiesterase isozyme 7 antibody
    • Phosphodiesterase7A antibody
    • Rolipram insensitive phosphodiesterase type 7 antibody
    • TM 22 antibody
    • TM22 antibody
    see all

Anti-PDE7A antibody images

  • All lanes : Anti-PDE7A antibody (ab14616) at 1/500 dilution

    Lane 1 : Rat Lungs
    Lane 2 : Rat Kidney
    Lane 3 : Rat Testis
    Lane 4 : Rat PC-PDE7A
    Lane 5 : Rat Heart
    Lane 6 : Rat Brain
    Lane 7 : Rat Heart


    Predicted band size : 55 kDa

References for Anti-PDE7A antibody (ab14616)

ab14616 has not yet been referenced specifically in any publications.

Product Wall

Merci beaucoup pour votre réponse.
Merci pour l'image avec le résultat sur le muscle squelettique. Je vais faire suite à ces deux bandes aspécifiques avec le laboratoire.
Je peux aussi vous conseiller de soumettre une Abreview avec ces résult...

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Merci de votre patience. Comme xx est absent cette semaine, je vais suivre et essayer de résoudre ce problème avec le ab14616.

Le laboratoire nous a confirmé qu'ils volent une bande très faible aux au-dessus des 100kD. Cette bande est en rie...

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Merci pour ces précisions et pour l'image que je vais immédiatement transmettre au laboratoire qui produit cet anticorps. Les 3 bandes observées autour des 55 kDa pourraient correspondre aux 3 isoformes de la PDE7A comme déc...

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Comme convenu par téléphone j'ai procédé à l'envoi d'une unité de ab14616 lot GR59978. Le numéro de commande de remplacement gratuit de ce produitest *******. Vous recevrez prochainement un mail de confi...

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Le laboratoire où est produit l'anti-PDE7A ab14616 m'a informé qu'un bon contrôle positif sont le rein et le coeur. Le blot obtenu avec cet anticorps est en pièce jointe. Est-ce que l'utilisation de BSA comme agent bloquant v...

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Thank you for your enquiry. I have contacted the originator of these products and I have obtained the following information. These products are shipped in a commercially sensitive formulated antibody stabilization buffer containing hepes, phosphate...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"