FunctionHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
Tissue specificityAbundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain isoform 2 predominates.
Involvement in diseaseDefects in PDE8B are the cause of striatal degeneration autosomal dominant (ADSD) [MIM:609161]. It is a movement disorder affecting the striatal part of the basal ganglia and characterized by bradykinesia, dysarthria and muscle rigidity. These symptoms resemble idiopathic Parkinson disease, but tremor is not present.
Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. Contains 1 PAS (PER-ARNT-SIM) domain.
DomainComposed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
Cell proliferation-inducing gene 22 protein antibody
High affinity cAMP specific and IBMX insensitive 3' 5' cyclic phosphodiesterase 8B antibody
High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8B antibody
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B antibody
HSPDE 8B antibody
PDE 8B antibody
Phosphodiesterase 8B antibody
Anti-PDE8B antibody images
Immunoprecipitation - PDE8B antibody (ab112024)
Immunoprecipitation of PDE8B.
Samples: Whole cell lysate from HeLa cells.
20% of IP loaded.
Antibodies: Affinity purified rabbit anti-PDE8B antibody
(ab112024) at 1 µg/ml. Lane 1- PDE8B was immunoprecipitated by rabbit anti-PDE8B antibody (ab112024)
at 6 mcg/mg lysate. Lane 2- PDE8B was
immunoprecipitated by an rabbit anti-PDE8B antibody that recognizes an upstream epitope. Lane 3- Rabbit IgG control. Detection: Chemiluminescence with exposure times of 3 minutes.
Western blot - PDE8B antibody (ab112024)
All lanes : Anti-PDE8B antibody (ab112024) at 0.4 µg/ml
Lane 1 : Whole cell extracts from HeLa cells at 50 µg Lane 2 : Whole cell extracts from HeLa cells at 15 µg Lane 3 : Whole cell extracts from HeLa cells at 5 µg
Predicted band size : 99 kDa
References for Anti-PDE8B antibody (ab112024)
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