Anti-PDGF Receptor alpha antibody [APA5] (ab90967)


  • Product nameAnti-PDGF Receptor alpha antibody [APA5]
    See all PDGF Receptor alpha primary antibodies
  • Description
    Rat monoclonal [APA5] to PDGF Receptor alpha
  • Tested applicationsSuitable for: WB, IHC-Fr, Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Fusion protein corresponding to Mouse PDGF Receptor alpha (extracellular). Fusion protein containing the extracellular domain of Mouse PDGF Receptor alpha and the Fc portion of Human IgG1 purified from the culture supernatant of transfected COS1 cells

  • Positive control
    • NIH3T3 cells



Our Abpromise guarantee covers the use of ab90967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notesFlow Cyt: Use 1µg for 106 cells in a 100 µl total staining volume.
    IHC-Fr: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 123 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionReceptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
    • Tissue specificityExpressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue.
    • Involvement in diseaseNote=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
    • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
      Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 protein kinase domain.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Alpha-type platelet-derived growth factor receptor antibody
      • CD140 antigen-like family member A antibody
      • CD140a antibody
      • CD140a antigen antibody
      • MGC74795 antibody
      • PDGF alpha chain antibody
      • PDGF-R-alpha antibody
      • PDGFR 2 antibody
      • PDGFR alpha antibody
      • PDGFR2 antibody
      • PDGFRA antibody
      • PDGFRA/BCR fusion antibody
      • PGFRA_HUMAN antibody
      • Platelet derived growth factor receptor 2 antibody
      • Platelet derived growth factor receptor alpha antibody
      • Platelet derived growth factor receptor alpha polypeptide antibody
      • Platelet derived growth factor receptor antibody
      • Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein antibody
      • RHEPDGFRA antibody
      see all

    Anti-PDGF Receptor alpha antibody [APA5] images

    • Staining of NIH/3T3 cells with 0.5 µg Rat IgG2a control antibody (open histogram) or 0.5 µg of ab90967 (colored histogram) followed by Biotin Anti-Rat IgG secondary antibody. Total viable cells were analysed.

    References for Anti-PDGF Receptor alpha antibody [APA5] (ab90967)

    This product has been referenced in:
    • Rondahl V  et al. Lrig2-deficient mice are protected against PDGFB-induced glioma. PLoS One 8:e73635 (2013). Read more (PubMed: 24023893) »
    • Miyawaki T  et al. Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina. J Neurosci 24:8124-34 (2004). Read more (PubMed: 15371513) »

    See all 3 Publications for this product

    Product Wall

    Thank you for contacting Abcam regarding ab90967.

    We have not tested this antibody directly in-house for cross reactivity against CD140b.The clone is APA5 and according to the development paper for this clone, this antibody is specific ...

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