Anti-PDGF Receptor alpha antibody [RM0004-3G28] (ab51875)

Overview

  • Product name
    Anti-PDGF Receptor alpha antibody [RM0004-3G28]
    See all PDGF Receptor alpha primary antibodies
  • Description
    Rat monoclonal [RM0004-3G28] to PDGF Receptor alpha
  • Specificity
    Does not bind to PDGF receptor beta
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Purified PDGF receptor alpha extracellular domain (Mouse)

Properties

Applications

Our Abpromise guarantee covers the use of ab51875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
WB
  • Application notes
    IHC-P: 1/50 - 1/100. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. The recommended protease is proteinase K, 20 ug/ml in PBS for 10 - 20 minutes.
    WB: 1/400 - 1/800. Predicted molecular weight: 180 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
    • Tissue specificity
      Expressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue.
    • Involvement in disease
      Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
    • Sequence similarities
      Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
      Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 protein kinase domain.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Alpha-type platelet-derived growth factor receptor antibody
      • CD140 antigen-like family member A antibody
      • CD140a antibody
      • CD140a antigen antibody
      • MGC74795 antibody
      • PDGF alpha chain antibody
      • PDGF-R-alpha antibody
      • PDGFR 2 antibody
      • PDGFR alpha antibody
      • PDGFR2 antibody
      • PDGFRA antibody
      • PDGFRA/BCR fusion antibody
      • PGFRA_HUMAN antibody
      • Platelet derived growth factor receptor 2 antibody
      • Platelet derived growth factor receptor alpha antibody
      • Platelet derived growth factor receptor alpha polypeptide antibody
      • Platelet derived growth factor receptor antibody
      • Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein antibody
      • RHEPDGFRA antibody
      see all

    Images

    • ab51875 at 1/100 dilution, staining PDGF Receptor alpha in LPS exposed mouse pancreatic tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

    References

    This product has been referenced in:
    • Daquinag AC  et al. Targeted Proapoptotic Peptides Depleting Adipose Stromal Cells Inhibit Tumor Growth. Mol Ther 24:34-40 (2016). Read more (PubMed: 26316391) »
    • Daquinag AC  et al. Depletion of white adipocyte progenitors induces beige adipocyte differentiation and suppresses obesity development. Cell Death Differ 22:351-63 (2015). Read more (PubMed: 25342467) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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