Anti-PDGF Receptor alpha antibody [RM0004-3G28] (ab51875)

Overview

  • Product name
    Anti-PDGF Receptor alpha antibody [RM0004-3G28]
    See all PDGF Receptor alpha primary antibodies
  • Description
    Rat monoclonal [RM0004-3G28] to PDGF Receptor alpha
  • Specificity
    Does not bind to PDGF receptor beta
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Purified PDGF receptor alpha extracellular domain (Mouse)

Properties

Applications

Our Abpromise guarantee covers the use of ab51875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
WB
  • Application notes
    IHC-P: 1/50 - 1/100. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. The recommended protease is proteinase K, 20 ug/ml in PBS for 10 - 20 minutes.
    WB: 1/400 - 1/800. Predicted molecular weight: 180 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
    • Tissue specificity
      Expressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue.
    • Involvement in disease
      Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
    • Sequence similarities
      Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
      Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 protein kinase domain.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Alpha-type platelet-derived growth factor receptor antibody
      • CD140 antigen-like family member A antibody
      • CD140a antibody
      • CD140a antigen antibody
      • MGC74795 antibody
      • PDGF alpha chain antibody
      • PDGF-R-alpha antibody
      • PDGFR 2 antibody
      • PDGFR alpha antibody
      • PDGFR2 antibody
      • PDGFRA antibody
      • PDGFRA/BCR fusion antibody
      • PGFRA_HUMAN antibody
      • Platelet derived growth factor receptor 2 antibody
      • Platelet derived growth factor receptor alpha antibody
      • Platelet derived growth factor receptor alpha polypeptide antibody
      • Platelet derived growth factor receptor antibody
      • Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein antibody
      • RHEPDGFRA antibody
      see all

    Anti-PDGF Receptor alpha antibody [RM0004-3G28] images

    • ab51875 at 1/100 dilution, staining PDGF Receptor alpha in LPS exposed mouse pancreatic tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

    References for Anti-PDGF Receptor alpha antibody [RM0004-3G28] (ab51875)

    This product has been referenced in:
    • Daquinag AC  et al. Targeted Proapoptotic Peptides Depleting Adipose Stromal Cells Inhibit Tumor Growth. Mol Ther 24:34-40 (2016). Read more (PubMed: 26316391) »
    • Daquinag AC  et al. Depletion of white adipocyte progenitors induces beige adipocyte differentiation and suppresses obesity development. Cell Death Differ 22:351-63 (2015). Read more (PubMed: 25342467) »

    See all 2 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab51875.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up