Overview

  • Product nameAnti-PDGFAA + PDGFBB antibody
  • Description
    Goat polyclonal to PDGFAA + PDGFBB
  • SpecificityThe antibody reacts with PKBa. It may recognize the PKBß isoform. The sequence is identical in mouse, rat, and bovine PKBa, highly conserved in PKBß, and diverges in the PKB? isoform.
  • Tested applicationsSuitable for: WB, Neutralising, Indirect ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Natural human PDGF

  • Positive control
    • PDGF-responsive NR6R-3T3 fibroblasts.

Properties

Applications

Our Abpromise guarantee covers the use of ab50201 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
Neutralising
Indirect ELISA
  • Application notesI-ELISA: Use at a concentration of 0.25 µg/ml.
    Neut: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPlatelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.
    • Tissue specificityExpressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.
    • Involvement in diseaseNote=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGF.
    • Sequence similaritiesBelongs to the PDGF/VEGF growth factor family.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • FormPDGFB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Secreted.
    • Alternative names
      • becaplermin antibody
      • c-sis antibody
      • FLJ12858 antibody
      • PDGF 1 antibody
      • PDGF 2 antibody
      • PDGF B antibody
      • PDGF B chain antibody
      • PDGF subunit B antibody
      • PDGF-2 antibody
      • Pdgfb antibody
      • PDGFB_HUMAN antibody
      • Platelet derived growth factor beta polypeptide antibody
      • platelet-derived growth factor 2 antibody
      • Platelet-derived growth factor B chain antibody
      • Platelet-derived growth factor beta polypeptide antibody
      • Platelet-derived growth factor subunit B antibody
      • Platelet-derived growth factor, beta polypeptide (oncogene SIS) antibody
      • Proto-oncogene c-Sis antibody
      • SIS antibody
      • SSV antibody
      see all

    References for Anti-PDGFAA + PDGFBB antibody (ab50201)

    ab50201 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"