The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
FunctionActs as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.
Tissue specificityHighly expressed in pancreas (at protein level).
Sequence similaritiesBelongs to the protein disulfide isomerase family. Contains 2 thioredoxin domains.
Post-translational modificationsThe disulfide-linked homodimer exhibits an enhanced chaperone activity. Glycosylated.