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- Primary antibodies
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Read our guarantee »Overview
Product name
PDP1 protein
Protein description
Recombinant full length protein (Human)
Uniprot accession
Q9P0J1
Protein length
466 amino acids
Expression host
E. coli
Properties
Purity
> 90% Purified via His tag
E.C. Number
3.1.3.43
Form
Liquid
Storage instructions
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Storage buffer
pH: 7.50
Constituents: 0.14% Sodium phosphate, 1.46% Sodium chloride, 30% Glycerol, 0.08% DTT, 0.02% EDTA, 0.05% Triton-X-100
Concentration
Concentration information loading...
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Energy transfer pathways >> Integration of energy
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Energy transfer pathways >> Energy Metabolism
Metabolism >> Pathways and Processes >> Mitochondrial Metabolism >> Mitochondrial markers
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Signal Transduction >> Metabolism >> Energy Metabolism
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Phosphatases
Tags & Cell Markers >> Subcellular Markers >> Organelles >> Mitochondria
Applications
Show applications key
Our Abpromise guarantee covers the use of ab110357 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
FuncS: Use at an assay dependent concentration. See MitoSciences activity protocol.
sELISA: Use at an assay dependent dilution.
Application notes
This peptide can be used with studies using ab110671.
Protein info
Function
Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
Involvement in disease
Defects in PDP1 are the cause of pyruvate dehydrogenase phosphatase deficiency (PDP deficiency) [MIM:608782]. PDP deficiency results in lactic acidosis leading to neurological dysfunction.
Sequence similarities
Belongs to the PP2C family.
Cellular localization
Mitochondrion matrix.
Target information above from: UniProt accessionQ9P0J1
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Protocols
References for PDP1 protein (ab110357)
ab110357 has not yet been referenced specifically in any publications.
Publishing research using ab110357? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"