• Product name
  • Description
    Rabbit polyclonal to PDZK1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 195-224 of Human PDZK1 (NP_002605.2).

  • Positive control
    • NCI-H292 cell lysate


  • Form
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab123798 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab123798 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 57 kDa.


  • Function
    A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
  • Tissue specificity
    Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas.
  • Sequence similarities
    Belongs to the NHER family.
    Contains 4 PDZ (DHR) domains.
  • Domain
    The PDZ 2 and 3 domains seem to be involved in the interaction with SLC26A3.
    Interaction with the C-terminus of CFTR could be mediated through independent binding of PDZ 1, 3 and 4 domains.
    The PDZ 1 and 3 domains seem to be involved in the interaction with SLCO1A1.
    The PDZ 1 domain interacts with BCR.
  • Cellular localization
    Cytoplasm. Membrane. Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1700023D20Rik antibody
    • 2610507N21Rik antibody
    • 4921513F16Rik antibody
    • AI267131 antibody
    • AI314638 antibody
    • AL022680 antibody
    • C terminal linking and modulating protein antibody
    • CAP70 antibody
    • CFTR associated protein of 70 kDa antibody
    • CFTR associated protein, 70-KD antibody
    • CFTR-associated protein of 70 kDa antibody
    • CLAMP antibody
    • D3Ertd537e antibody
    • Dietary Pi-regulated RNA-1 antibody
    • Diphor-1 antibody
    • mPDZK1 antibody
    • Na(+)/H(+) exchange regulatory cofactor NHE-RF3 antibody
    • Na(+)/H(+) exchanger regulatory factor 3 antibody
    • Na/Pi cotransporter C-terminal-associated protein 1 antibody
    • Na/Pi cotransporter C-terminal-associated protein antibody
    • NaPi Cap1 antibody
    • NaPi-Cap1 antibody
    • NaPiCap1 antibody
    • NHERF 3 antibody
    • NHERF-3 antibody
    • NHERF3 antibody
    • NHRF3_HUMAN antibody
    • OTTHUMP00000015572 antibody
    • PDZ domain containing 1 antibody
    • PDZ domain containing protein 1 antibody
    • PDZ domain-containing protein 1 antibody
    • PDZD1 antibody
    • PDZK1 antibody
    • Sodium hydrogen exchanger regulatory factor 3 antibody
    • Sodium-hydrogen exchanger regulatory factor 3 antibody
    see all


  • Anti-PDZK1 antibody (ab123798) at 1/100 dilution + NCI-H292 cell line lysates at 35 µg

    Predicted band size : 57 kDa


ab123798 has not yet been referenced specifically in any publications.

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